ArticleJournal of virology1991
VP4-specific intestinal antibody response to rotavirus in a murine model of heterotypic infection.
Article in Journal of virology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- High-dimensional immune profiling of total and rotavirus VP6-specific intestinal and circulating B cells by mass cytometry.Mucosal immunology · 2016Article
- Antibody-secreting cell responses to rotavirus proteins in gnotobiotic pigs inoculated with attenuated or virulent human rotavirus.Journal of clinical microbiology · 2001Article
- Subunit rotavirus vaccine administered parenterally to rabbits induces active protective immunity.Journal of virology · 1998Article
- Effects of the route of infection on immunoglobulin G subclasses and specificity of the reovirus-specific humoral immune response.Journal of virology · 1996Article
- Rotavirus diarrhea is caused by nonreplicating viral particles.Journal of virology · 1995Article
- Enumeration of isotype-specific antibody-secreting cells derived from gnotobiotic piglets inoculated with porcine rotaviruses.Veterinary immunology and immunopathology · 1995Article
- Rotaviruses: immunological determinants of protection against infection and disease.Advances in virus research · 1994Review
- Infectious diarrhoea. Viruses.Bailliere's clinical gastroenterology · 1993Review
- Persistence of intestinal antibody response to heterologous rotavirus infection in a murine model beyond 1 year.Journal of clinical microbiology · 1993Article
- Expression of the OSU rotavirus outer capsid protein VP4 by an adenovirus recombinant.Journal of virology · 1992Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have adapted a murine model of heterotypic rotavirus infection for the purpose of evaluating the intestinal antibody response to an infection that mimics human vaccination. Neonatal mice were infected with the rhesus rotavirus (RRV). The enzyme-linked immunospot assay was used in order to avoid common artifacts in the quantitation of intestinal immune responses inherent in measurements of luminal or serum immunoglobulins and to obtain easily quantifiable data in a flexible and convenient format. Functionally active lymphocytes were harvested from the spleen, small intestinal lamina propria, Peyer's patches, and mesenteric lymph nodes and processed into single-cell suspensions. Antibody-secreting cells (ASC) were quantitated from 5 to 50 days after infection for total, RRV-specific, baculovirus-expressed VP4-specific, and single-shell RRV-specific ASC secreting either immunoglobulin G (IgG), IgM, or IgA. The response to VP4 constituted less than 1.5% of the total virus-specific response, which was located almost exclusively in the gut and was 90% IgA. Intestinal ASC were directed overwhelmingly toward proteins incorporated in the single-shell particle, predominantly VP2 and VP6. We conclude that the antibody response to VP4, thought to be the site of the important neutralization sites conserved among several rotavirus serotypes, is an extremely small portion of the overall antibody response in the intestinal tract.
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