ArticleLipids in health and disease2006
Alzheimer's disease and type 2 diabetes mellitus: the cholinesterase connection?
Article in Lipids in health and disease, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 62 citations in OpenAlex.
- Incretin Therapy and Insulin Signaling: Therapeutic Targets for Diabetes And Associated Dementia.Current diabetes reviews · 2024Review
- Cardio- and Neurometabolic Adipobiology: Consequences and Implications for Therapy.International journal of molecular sciences · 2021Review
- DPP4 Inhibitors Can Be a Drug of Choice for Type 3 Diabetes: A Mini Review.American journal of Alzheimer's disease and other dementias · 2017Review
- The diabetic brain and cognition.Journal of neural transmission (Vienna, Austria : 1996) · 2017Review
- Inhibition of Butyrylcholinesterase with Fluorobenzylcymserine, An Experimental Alzheimer's Drug Candidate: Validation of Enzoinformatics Results by Classical and Innovative Enzyme Kinetic Analyses.CNS & neurological disorders drug targets · 2017Article
- Emerging links between type 2 diabetes and Alzheimer's disease.World journal of diabetes · 2015Review
- Article
- Role of anti-diabetic drugs as therapeutic agents in Alzheimer's disease.EXCLI journal · 2015Review
- Assay development and multivariate scoring for high-content discovery of chemoprotectants of endoplasmic-reticulum-stress-mediated amylin-induced cytotoxicity in pancreatic beta cells.Assay and drug development technologies · 2014Article
- Linking Alzheimer's disease and type 2 diabetes mellitus via aberrant insulin signaling and inflammation.CNS & neurological disorders drug targets · 2014Review
- Status of acetylcholinesterase and butyrylcholinesterase in Alzheimer's disease and type 2 diabetes mellitus.CNS & neurological disorders drug targets · 2014Review
- Views and opinion on BDNF as a target for diabetic cognitive dysfunction.Bioinformation · 2013Article
- Acetylcholinesterase involvement in apoptosis.Frontiers in molecular neuroscience · 2012Article
- Targeting BuChE-inflammatory pathway by SK0506 to manage type 2 diabetes and Alzheimer disease.Neurochemical research · 2009Article
- Identification of biomarkers for type 2 diabetes and its complications: a bioinformatic approach.International journal of biomedical science : IJBS · 2007Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease and type 2 diabetes mellitus tend to occur together. We sought to identify protein(s) common to both conditions that could suggest a possible unifying pathogenic role. Using human neuronal butyrylcholinesterase (AAH08396.1) as the reference protein we used BLAST Tool for protein to protein comparison in humans. We found three groups of sequences among a series of 12, with an E-value between 0-12, common to both Alzheimer's disease and diabetes: butyrylcholinesterase precursor K allele (NP_000046.1), acetylcholinesterase isoform E4-E6 precursor (NP_000656.1), and apoptosis-related acetylcholinesterase (1B41|A). Butyrylcholinesterase and acetylcholinesterase related proteins were found common to both Alzheimer's disease and diabetes; they may play an etiological role via influencing insulin resistance and lipid metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.