ArticlePLoS computational biology2006
Geometrically repatterned immunological synapses uncover formation mechanisms.
Article in PLoS computational biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Immunocyte senescence: A new perspective on the remodeling of the ovarian cancer microenvironment and therapeutic intervention.Journal of pharmaceutical analysis · 2026Review
- Characterization of mechanisms positioning costimulatory complexes in immune synapses.iScience · 2021Article
- Dimensionality of Motion and Binding Valency Govern Receptor-Ligand Kinetics As Revealed by Agent-Based Modeling.Frontiers in immunology · 2017Article
- Line tension and stability of domains in cell-adhesion zones mediated by long and short receptor-ligand complexes.PloS one · 2011Article
- Article
- T cell receptor microcluster transport through molecular mazes reveals mechanism of translocation.Biophysical journal · 2008Article
- Effects of intracellular calcium and actin cytoskeleton on TCR mobility measured by fluorescence recovery.PloS one · 2008Article
- Testing the organization of the immunological synapse.Current opinion in immunology · 2007Article
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Authors and funding
2 authors.
Funding
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Abstract
The interaction of T cells and antigen-presenting cells is central to adaptive immunity and involves the formation of immunological synapses in many cases. The surface molecules of the cells form a characteristic spatial pattern whose formation mechanisms and function are largely unknown. We perform computer simulations of recent experiments on geometrically repatterned immunological synapses and explain the emerging structure as well as the formation dynamics. Only the combination of in vitro experiments and computer simulations has the potential to pinpoint the kind of interactions involved. The presented simulations make clear predictions for the structure of the immunological synapse and elucidate the role of a self-organizing attraction between complexes of T cell receptor and peptide-MHC molecule, versus a centrally directed motion of these complexes.
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