ArticleMolecular and cellular biochemistry2007
Curcumin-induced apoptosis in human leukemia cell HL-60 is associated with inhibition of telomerase activity.
Article in Molecular and cellular biochemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 79 citations in OpenAlex.
- Telomeres, Telomerase, and Curcumin: A New Frontier in Cancer Therapy: A Narrative Review.Biomedicines · 2025Review
- Telomerase Inhibition in the Treatment of Leukemia: A Comprehensive Review.Antioxidants (Basel, Switzerland) · 2024Review
- Combining old and new concepts in targeting telomerase for cancer therapy: transient, immediate, complete and combinatory attack (TICCA).Cancer cell international · 2023Review
- RNA-Sequencing Analysis of Gene-Expression Profiles in the Dorsal Gland ofLife (Basel, Switzerland) · 2022Article
- Curcumin as a therapeutic agent in leukemia.Journal of cellular physiology · 2019Review
- Effect of therapies-mediated modulation of telomere and/or telomerase on cancer cells radiosensitivity.Oncotarget · 2018Review
- Telomerase Inhibitors from Natural Products and Their Anticancer Potential.International journal of molecular sciences · 2017Review
- Efficacy of curcumin in inducing apoptosis and inhibiting the expression of VEGF in human pterygium fibroblasts.International journal of molecular medicine · 2017Article
- New insights into therapeutic activity and anticancer properties of curcumin.Journal of experimental pharmacology · 2017Review
- Unraveling the Anticancer Effect of Curcumin and Resveratrol.Nutrients · 2016Review
- Therapeutic Targeting of Telomerase.Genes · 2016Review
- Curcumin and Osteosarcoma: Can Invertible Polymeric Micelles Help?Materials (Basel, Switzerland) · 2016Review
- Therapeutic targeting of replicative immortality.Seminars in cancer biology · 2015Review
- Curcumin: a potential candidate in prevention of cancer via modulation of molecular pathways.BioMed research international · 2014Review
- Curcumin induces the apoptosis of human monocytic leukemia THP-1 cells via the activation of JNK/ERK pathways.BMC complementary and alternative medicine · 2012Article
- Pharmaceutical regulation of telomerase and its clinical potential.Journal of cellular and molecular medicine · 2012Review
- Curcumin reduces expression of Bcl-2, leading to apoptosis in daunorubicin-insensitive CD34+ acute myeloid leukemia cell lines and primary sorted CD34+ acute myeloid leukemia cells.Journal of translational medicine · 2011Article
- Curcumin regulates low-linear energy transfer γ-radiation-induced NFκB-dependent telomerase activity in human neuroblastoma cells.International journal of radiation oncology, biology, physics · 2011Article
- The targets of curcumin.Current drug targets · 2011Review
- Curcumin-the paradigm of a multi-target natural compound with applications in cancer prevention and treatment.Toxins · 2010Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Curcumin (diferuloylmethane), a natural cancer chemopreventive compound, has been tested for its action in acute myeloblastic leukemia cell line HL-60. The results clearly show that curcumin induces apoptosis in these cells as evidenced by the release of cytochrome c from mitochondria to the cytosol and increase in the DNA content in sub G1 region as observed in FACS analysis. Apoptosis is apparently mediated by up-regulation of apoptotic gene bax and simultaneous down-regulation of anti-apoptotic gene bcl-2 followed by activation of caspases 3 and 8 and degradation of PARP. Telomerase, a reverse transcriptase, has been found to be activated in more than 80% of human cancers and, therefore, can be considered as a potential marker for tumorigenesis. Certain natural compounds have the potential of inhibiting telomerase activity leading to suppression of cell viability and induction of apoptosis. The present study shows that curcumin-induced apoptosis coincides with the inhibition of telomerase activity in a dose dependent manner.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.