ArticleDiabetologia2006
Patterns of growth among children who later develop type 2 diabetes or its risk factors.
Article in Diabetologia, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 5 of them syntheses that pooled it.
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Who cites it
97 citing papers in PubMed, 5 syntheses or guidelines pooled it, 256 citations in OpenAlex.
- A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.Translational psychiatry · 2012Pooled it
- Meta-analysis of genome-wide association studies for personality.Molecular psychiatry · 2012Pooled it
- A common variant upstream of the PAX6 gene influences islet function in man.Diabetologia · 2012Pooled it
- Meta-analysis of genome-wide association studies identifies common variants in CTNNA2 associated with excitement-seeking.Translational psychiatry · 2011Pooled it
- Pooled it
- Blood pressure and the capacity-load model in 8-year-old children from Nepal: Testing the contributions of kidney size and intergenerational effects.American journal of human biology : the official journal of the Human Biology Council · 2016Trial
- Two-Year Data from a Long-Term Phase IV Study of Recombinant Human Growth Hormone in Short Children Born Small for Gestational Age.Advances in therapy · 2016Trial
- Early development and dynamics of nasopharyngeal microbiota in infants during the COVID-19 pandemic: a 2-year prospective birth cohort study.Respiratory research · 2025Article
- Humero-femoral index and diabetes risk in the US population- a case study.Journal of diabetes and metabolic disorders · 2023Article
- Inverse association between adult height and diabetes risk in a cohort study of Chinese population.Scientific reports · 2023Article
- Association between severe acute malnutrition in childhood and hematological disorders in adulthood: the Lwiro follow-up study in the Eastern Democratic Republic of the Congo.BMC nutrition · 2023Article
- BMI change during childhood, DNA methylation change at TXNIP, and glucose change during midlife.Obesity (Silver Spring, Md.) · 2023Article
- BMI trajectory and inflammatory effects on metabolic syndrome in adolescents.Pediatric research · 2023Article
- Weight gain in infancy and markers of cardiometabolic health in young adulthood.Acta paediatrica (Oslo, Norway : 1992) · 2022Article
- Pediatric growth patterns in youth-onset type 2 diabetes mellitus: Implications for physiologically-based pharmacokinetic models.Clinical and translational science · 2022Article
- IUGR with catch-up growth programs impaired insulin sensitivity through LRP6/IRS-1 in male rats.Endocrine connections · 2022Article
- Birthweight predicts glomerular filtration rate in adult-life: population based cross sectional study.Renal failure · 2021Article
- Children conceived by ART grow differently in early life than naturally conceived children but reach the same height and weight by age 17. Reassuring? Not so sure.Human reproduction (Oxford, England) · 2021Article
- Combined effects of genotype and childhood adversity shape variability of DNA methylation across age.Translational psychiatry · 2021Article
- Prenatal Nicotine Exposure Induces Low Birthweight and Hyperinsulinemia in Male Rats.Frontiers in endocrinology · 2021Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
Abstract
aims/hypothesisWe studied fetal and childhood growth patterns that are associated with IGT and type 2 diabetes in adult life.
methodsWe examined clinically 2,003 subjects born in Helsinki between 1934 and 1944. They had on average 11 measurements of height and weight between birth and 2 years of age, and seven measurements between 2 and 11 years of age. Glucose tolerance in adult life was assessed by a 75-g oral glucose tolerance test.
resultsWe identified 311 subjects with type 2 diabetes and 496 with IGT. Both IGT and type 2 diabetes were associated with low birthweight (p < 0.0001 adjusting for current BMI). The risk of these conditions was increased by low weight gain between birth and 2 years. A 1 SD increase in weight at 2 years was associated with an odds ratio for either type 2 diabetes or IGT of 0.76 (95% CI 0.69-0.84). This effect was greatest in people who had low birthweight. Low growth in the first 6 months after birth was a critical period for the development of insulin resistance in later life; other critical periods were associated with slow fetal growth and rapid increase in BMI between age 2 and 11 years. CONCLUSIONS/
interpretationLow weight gain during infancy increases the risk of IGT and type 2 diabetes. The effect is greater in people who had low birthweight. The first 6 months after birth may be the most critical period for growth, in relation to development of glucose intolerance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.