ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2007
Prenatal programming of rat proximal tubule Na+/H+ exchanger by dexamethasone.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 65 citations in OpenAlex.
- [The association between preterm birth and hypertension].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Review
- Pathomechanisms of Prenatally Programmed Adult Diseases.Antioxidants (Basel, Switzerland) · 2023Review
- Sex differences in prenatal programming of hypertension by dexamethasone.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- Prenatal alcohol exposure affects renal function in overweight schoolchildren: birth cohort analysis.Pediatric nephrology (Berlin, Germany) · 2020Article
- Uteroplacental insufficiency temporally exacerbates salt-induced hypertension associated with a reduced natriuretic response in male rat offspring.The Journal of physiology · 2018Article
- Role of renal sympathetic nerve activity in prenatal programming of hypertension.Pediatric nephrology (Berlin, Germany) · 2018Review
- The activity of organic anion transporter-3: Role of dexamethasone.Journal of pharmacological sciences · 2018Article
- Developmental Programming of Renal Function and Re-Programming Approaches.Frontiers in pediatrics · 2018Review
- Increased maternal nighttime cortisol concentrations in late gestation alter glucose and insulin in the neonatal lamb.Physiological reports · 2015Article
- Preterm Birth Is Associated with Higher Uric Acid Levels in Adolescents.The Journal of pediatrics · 2015Observational
- Antenatal glucocorticoid treatment alters Na+ uptake in renal proximal tubule cells from adult offspring in a sex-specific manner.American journal of physiology. Renal physiology · 2015Article
- Renal NHE expression and activity in neonatal NHE3- and NHE8-null mice.American journal of physiology. Renal physiology · 2015Article
- Effect of postnatal maternal protein intake on prenatal programming of hypertension.Reproductive sciences (Thousand Oaks, Calif.) · 2014Article
- Enalapril attenuates the exaggerated sympathetic response to physical stress in prenatally programmed hypertensive rats.Hypertension (Dallas, Tex. : 1979) · 2014Article
- How the kidney is impacted by the perinatal maternal environment to develop hypertension.Biology of reproduction · 2013Review
- Prenatal programming of hypertension induces sympathetic overactivity in response to physical stress.Hypertension (Dallas, Tex. : 1979) · 2013Article
- Proximal tubule Na+/H+ exchanger activity in adult NHE8-/-, NHE3-/-, and NHE3-/-/NHE8-/- mice.American journal of physiology. Renal physiology · 2012Article
- Prenatal programming of rat cortical collecting tubule sodium transport.American journal of physiology. Renal physiology · 2012Article
- Acid increases NHE8 surface expression and activity in NRK cells.American journal of physiology. Renal physiology · 2012Article
- Segmental sodium reabsorption by the renal tubule in prenatally programmed hypertension in the rat.Pediatric nephrology (Berlin, Germany) · 2012Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Prenatal administration of dexamethasone causes hypertension in rats when they are studied as adults. Although an increase in tubular sodium reabsorption has been postulated to be a factor programming hypertension, this has never been directly demonstrated. The purpose of this study was to examine whether prenatal programming by dexamethasone affected postnatal proximal tubular transport. Pregnant Sprague-Dawley rats were injected with intraperitoneal dexamethasone (0.2 mg/kg) daily for 4 days between the 15th and 18th days of gestation. Prenatal dexamethasone resulted in an elevation in systolic blood pressure when the rats were studied at 7-8 wk of age compared with vehicle-treated controls: 131 +/- 3 vs. 115 +/- 3 mmHg (P < 0.001). The rate of proximal convoluted tubule volume absorption, measured using in vitro microperfusion, was 0.61 + 0.07 nl.mm(-1).min(-1) in control rats and 0.93+ 0.07 nl.mm(-1).min(-1) in rats that received prenatal dexamethasone (P < 0.05). Na(+)/H(+) exchanger activity measured in perfused tubules in vitro using the pH-sensitive dye BCECF showed a similar 50% increase in activity in proximal convoluted tubules from rats treated with prenatal dexamethasone. Although there was no change in abundance of NHE3 mRNA, the predominant luminal proximal tubule Na(+)/H(+) exchanger, there was an increase in NHE3 protein abundance on brush-border membrane vesicles in 7- to 8-wk-old rats receiving prenatal dexamethasone. In conclusion, prenatal administration of dexamethasone in rats increases proximal tubule transport when rats are studied at 7-8 wk old, in part by stimulating Na(+)/H(+) exchanger activity. The increase in proximal tubule transport may be a factor mediating the hypertension by prenatal programming with dexamethasone.
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