ReviewThe Journal of physiology2007
Kit mutants and gastrointestinal physiology.
Review in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 99 citations in OpenAlex.
- Functional roles of interstitial cells of Cajal in the GI tract of rats.American journal of physiology. Gastrointestinal and liver physiology · 2025Article
- Plasticity of colonic enteric nervous system following spinal cord injury in male and female rats.Neurogastroenterology and motility · 2023Article
- Investigation of Novel c-Kit-expressing Smooth Muscle Cells in Murine Cecum.Acta histochemica et cytochemica · 2020Article
- Interstitial cells of Cajal in WJournal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2020Article
- Cyclic Stretch Promotes Proliferation and Contraction of Human Bladder Smooth Muscle Cells by Cajal-Mediated c-kit Expression in Interstitial Cells.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Idiopathic gastroparesis is associated with specific transcriptional changes in the gastric muscularis externa.Neurogastroenterology and motility · 2018Article
- Article
- Persistent distention of colon damages interstitial cells of Cajal through CaJournal of cellular and molecular medicine · 2017Article
- Hwangryunhaedok-tang induces the depolarization of pacemaker potentials through 5-HTWorld journal of gastroenterology · 2017Article
- Distribution and number of Cajal-like cells in testis tissue with azoospermia.The Kaohsiung journal of medical sciences · 2017Article
- ANO1 in intramuscular interstitial cells of Cajal plays a key role in the generation of slow waves and tone in the internal anal sphincter.The Journal of physiology · 2017Article
- Differences in time to peak carbachol-induced contractions between circular and longitudinal smooth muscles of mouse ileum.Naunyn-Schmiedeberg's archives of pharmacology · 2016Article
- Article
- Comparative Microarray Analysis of Proliferating and Differentiating Murine ENS Progenitor Cells.Stem cells international · 2016Article
- Hydroxy-α sanshool induces colonic motor activity in rat proximal colon: a possible involvement of KCNK9.American journal of physiology. Gastrointestinal and liver physiology · 2015Article
- Gastrointestinal motility and its enteric actors in mechanosensitivity: past and present.Pflugers Archiv : European journal of physiology · 2015Review
- Clinical presentations of gastric small gastrointestinal stromal tumors mimics functional dyspepsia symptoms.World journal of gastroenterology · 2014Article
- The gastric isthmus from D+ and D- broiler lines divergently selected for digestion efficiency shows histological and morphological differences.Poultry science · 2014Article
- Decreased SCF/c-kit signaling pathway contributes to loss of interstitial cells of Cajal in gallstone disease.International journal of clinical and experimental medicine · 2014Article
- Disruption of interstitial cells of Cajal networks after massive small bowel resection.World journal of gastroenterology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
There has been considerable speculation about the function of interstitial cells of Cajal (ICC) since their discovery more than 100 years ago. It has been difficult to study these cells under native conditions, but great insights about the function of ICC have come from studies of genetic models with loss-of function mutations in the Kit signalling pathway. First it was discovered that signalling via Kit (a receptor tyrosine kinase) was vital for the development and maintenance of the ICC phenotype in gastrointestinal (GI) muscles. In compound heterozygotes (W/W(V) and Sl/Sl(d) animals), where there are partial loss-of-function mutations in Kit receptors or Kit ligand (stem cell factor), ICC failed to develop in various regions of the GI tract, but no major changes in the smooth muscle layers or enteric nervous system occurred in the absence of these cells. Animals with these mutations provided an unprecedented opportunity to understand the role of ICC in GI motor function, and it is now clear from these studies that ICC serve as: (i) pacemaker cells, generating the spontaneous electrical rhythms of the gut known as slow waves; (ii) a propagation pathway for slow waves so that large areas of the musculature can be entrained to a dominant pacemaker frequency; (iii) mediators of excitatory cholinergic and inhibitory nitrergic neural inputs from the enteric nervous system, and (iv) stretch receptors that modulate membrane potential and electrical slow wave frequency. This review describes the use of genetic models to understand the important physiological role of ICC in the GI tract.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.