ArticleDevelopmental biology2007
Signals and myogenic regulatory factors restrict pax3 and pax7 expression to dermomyotome-like tissue in zebrafish.
Article in Developmental biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
70 citing papers in PubMed, 167 citations in OpenAlex.
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- Standardization of zebrafish drug testing parameters for muscle diseases.Disease models & mechanisms · 2024Article
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- Downregulation of Zebrafish Cytosolic Sialidase Neu3.2 Affects Skeletal Muscle Development.International journal of molecular sciences · 2023Article
- Isolation, Culture, and Analysis of Zebrafish Myofibers and Associated Muscle Stem Cells to Explore Adult Skeletal Myogenesis.Methods in molecular biology (Clifton, N.J.) · 2023Article
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- From Bipotent Neuromesodermal Progenitors to Neural-Mesodermal Interactions during Embryonic Development.International journal of molecular sciences · 2021Review
- 3D in vitro models of skeletal muscle: myopshere, myobundle and bioprinted muscle construct.Veterinary research · 2021Review
- Loss of splicing factor IK impairs normal skeletal muscle development.BMC biology · 2021Article
- Somite Compartments in Amphioxus and Its Implications on the Evolution of the Vertebrate Skeletal Tissues.Frontiers in cell and developmental biology · 2021Article
- Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis.eLife · 2020Article
- Review
- Potassium Channel-Associated Bioelectricity of the Dermomyotome Determines Fin Patterning in Zebrafish.Genetics · 2020Article
- The Developmental Phases of Zebrafish Myogenesis.Journal of developmental biology · 2019Review
- Muscle precursor cell movements in zebrafish are dynamic and require Six family genes.Development (Cambridge, England) · 2019Article
- Myogenin promotes myocyte fusion to balance fibre number and size.Nature communications · 2018Article
- A robust Pax7EGFP mouse that enables the visualization of dynamic behaviors of muscle stem cells.Skeletal muscle · 2018Article
10 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Pax3/7 paired homeodomain transcription factors are important markers of muscle stem cells. Pax3 is required upstream of myod for lateral dermomyotomal cells in the amniote somite to form particular muscle cells. Later Pax3/7-dependent cells generate satellite cells and most body muscle. Here we analyse early myogenesis from, and regulation of, a population of Pax3-expressing dermomyotome-like cells in the zebrafish. Zebrafish pax3 is widely expressed in the lateral somite and, along with pax7, becomes restricted anteriorly and then to the external cells on the lateral somite surface. Midline-derived Hedgehog signals appear to act directly on lateral somite cells to repress Pax3/7. Both Hedgehog and Fgf8, signals that induce muscle formation within the somite, suppress Pax3/7 and promote expression of myogenic regulatory factors (MRFs) myf5 and myod in specific muscle precursor cell populations. Loss of MRF function leads to loss of myogenesis by specific populations of muscle fibres, with parallel up-regulation of Pax3/7. Myod is required for lateral fast muscle differentiation from pax3-expressing cells. In contrast, either Myf5 or Myod is sufficient to promote slow muscle formation from adaxial cells. Thus, myogenic signals act to drive somite cells to a myogenic fate through up-regulation of distinct combinations of MRFs. Our data show that the relationship between Pax3/7 genes and myogenesis is evolutionarily ancient, but that changes in the MRF targets for particular signals contribute to myogenic differences between species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.