ArticleImmunome research2006
In silico identification of opossum cytokine genes suggests the complexity of the marsupial immune system rivals that of eutherian mammals.
Article in Immunome research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 46 citations in OpenAlex.
- Evolution of γ chain cytokines: Mechanisms, methods and applications.Computational and structural biotechnology journal · 2022Review
- Annotation of immune genes in the extinct thylacine (Thylacinus cynocephalus).Immunogenetics · 2021Article
- Identification of interleukin genes in Pogona vitticeps using a de novo transcriptome assembly from RNA-seq data.Immunogenetics · 2016Article
- Article
- Immunome database for marsupials and monotremes.BMC immunology · 2011Article
- Transcriptomic analysis supports similar functional roles for the two thymuses of the tammar wallaby.BMC genomics · 2011Article
- Phylogenetic and functional analysis identifies Ets-1 as a novel regulator of the Th2 cytokine gene locus.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Structural mapping of post-translational modifications in human interleukin-24: role of N-linked glycosylation and disulfide bonds in secretion and activity.The Journal of biological chemistry · 2009Article
- On the genomics of immunoglobulins in the gray, short-tailed opossum Monodelphis domestica.Immunogenetics · 2009Article
- The opossum genome: insights and opportunities from an alternative mammal.Genome research · 2008Review
- Characterization of the opossum immune genome provides insights into the evolution of the mammalian immune system.Genome research · 2007Article
- Analysis of a set of Australian northern brown bandicoot expressed sequence tags with comparison to the genome sequence of the South American grey short tailed opossum.BMC genomics · 2007Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCytokines are small proteins that regulate immunity in vertebrate species. Marsupial and eutherian mammals last shared a common ancestor more than 180 million years ago, so it is not surprising that attempts to isolate many key marsupial cytokines using traditional laboratory techniques have been unsuccessful. This paucity of molecular data has led some authors to suggest that the marsupial immune system is 'primitive' and not on par with the sophisticated immune system of eutherian (placental) mammals.
resultsThe sequencing of the first marsupial genome has allowed us to identify highly divergent immune genes. We used gene prediction methods that incorporate the identification of gene location using BLAST, SYNTENY + BLAST and HMMER to identify 23 key marsupial immune genes, including IFN-gamma, IL-2, IL-4, IL-6, IL-12 and IL-13, in the genome of the grey short-tailed opossum (Monodelphis domestica). Many of these genes were not predicted in the publicly available automated annotations.
conclusionThe power of this approach was demonstrated by the identification of orthologous cytokines between marsupials and eutherians that share only 30% identity at the amino acid level. Furthermore, the presence of key immunological genes suggests that marsupials do indeed possess a sophisticated immune system, whose function may parallel that of eutherian mammals.
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