ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Early and rapid engraftment of bone marrow-derived microglia in scrapie.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 90 citations in OpenAlex.
- Article
- Impacts of systemic milieu on cerebrovascular and brain aging: insights from heterochronic parabiosis, blood exchange, and plasma transfer experiments.GeroScience · 2025Review
- Article
- Origin and Emergence of Microglia in the CNS-An Interesting (Hi)story of an Eccentric Cell.Current issues in molecular biology · 2023Review
- Reflections on Cerebellar Neuropathology in Classical Scrapie.Biomolecules · 2021Review
- The Effects of Immune System Modulation on Prion Disease Susceptibility and Pathogenesis.International journal of molecular sciences · 2020Review
- Is Alzheimer disease a failure of mobilizing immune defense? Lessons from cognitively fit oldest-old.Dialogues in clinical neuroscience · 2019Article
- Microglia Regulate Neuroglia Remodeling in Various Ocular and Retinal Injuries.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Permanent neuroglial remodeling of the retina following infiltration of CSF1R inhibition-resistant peripheral monocytes.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Flow Cytometric Detection of PrPJournal of virology · 2018Article
- Activation of microglia by retroviral infection correlates with transient clearance of prions from the brain but does not change incubation time.Brain pathology (Zurich, Switzerland) · 2017Article
- Indications for cellular migration from the central nervous system to its draining lymph nodes in CD11c-GFPExperimental brain research · 2017Article
- Contributions of Mouse and Human Hematopoietic Cells to Remodeling of the Adult Auditory Nerve After Neuron Loss.Molecular therapy : the journal of the American Society of Gene Therapy · 2016Article
- Central nervous system myeloid cells as drug targets: current status and translational challenges.Nature reviews. Drug discovery · 2016Review
- Macrophages: An Inflammatory Link Between Angiogenesis and Lymphangiogenesis.Microcirculation (New York, N.Y. : 1994) · 2016Review
- Origin of microglia: current concepts and past controversies.Cold Spring Harbor perspectives in biology · 2015Review
- Deposition pattern and subcellular distribution of disease-associated prion protein in cerebellar organotypic slice cultures infected with scrapie.Frontiers in neuroscience · 2015Article
- Article
- Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease.Nature reviews. Neuroscience · 2014Review
- Obesity induced by a high-fat diet is associated with increased immune cell entry into the central nervous system.Brain, behavior, and immunity · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prion neuroinvasion is accompanied by maximal activation of microglia, the significance of which for pathogenesis is unknown. Here, we used bone marrow (BM) cells expressing GFP (green fluorescent protein) to study the turnover of microglia in mouse scrapie. We found that >or=50% of all brain microglia were replaced by BM-derived cells before clinical disease onset. In terminally sick mice, microglia density increased threefold to fourfold. Hence BM-derived microglia rapidly and efficaciously colonize the brain in scrapie. Whereas reconstitution of wild-type mice with prion protein-deficient (Prnp(o/o)) BM did not alter scrapie pathogenesis, Prnp(o/o) mice transplanted with wild-type BM cells were resistant to peripherally administered prions despite high levels of infectivity in the spleen. Cerebellar homogenates from prion-inoculated Prnp(o/o) mice reconstituted with >10% of wild-type microglia failed to infect transgenic mice overexpressing the cellular prion protein. Hence, in contrast to previous reports, microglia are not competent for efficient prion transport and replication in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.