ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Blocking memory reconsolidation reverses memory-associated changes in glutamate receptor expression.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Neuroligin Plays a Role in Ethanol-Induced Disruption of Memory and Corresponding Modulation of Glutamate Receptor Expression.Frontiers in behavioral neuroscience · 2022Article
- Molecular Mechanisms of Reconsolidation-Dependent Memory Updating.International journal of molecular sciences · 2020Review
- Function and mechanisms of memory destabilization and reconsolidation after retrieval.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2020Review
- Non-canonical activation of CREB mediates neuroprotection in a Caenorhabditis elegans model of excitotoxic necrosis.Journal of neurochemistry · 2019Article
- Temporal Flexibility of Systems Consolidation and the Synaptic Occupancy/Reset Theory (SORT): Cues About the Nature of the Engram.Frontiers in synaptic neuroscience · 2019Article
- Reconsolidation and the Dynamic Nature of Memory.Cold Spring Harbor perspectives in biology · 2015Review
- A genome-wide screen identifies PAPP-AA-mediated IGFR signaling as a novel regulator of habituation learning.Neuron · 2015Article
- The FMRFamide-Like Peptide Family in Nematodes.Frontiers in endocrinology · 2014Review
- Memory as a new therapeutic target.Dialogues in clinical neuroscience · 2013Review
- Memory reconsolidation in aversive and appetitive settings.Frontiers in behavioral neuroscience · 2013Review
- Addiction: a drug-induced disorder of memory reconsolidation.Current opinion in neurobiology · 2013Article
- Common influences of non-competitive NMDA receptor antagonists on the consolidation and reconsolidation of cocaine-cue memory.Psychopharmacology · 2013Article
- Learning and reconsolidation implicate different synaptic mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The FMRFamide-related neuropeptide FLP-20 is required in the mechanosensory neurons during memory for massed training in C. elegans.Learning & memory (Cold Spring Harbor, N.Y.) · 2013Article
- Reconsolidation of long-term memory in Aplysia.Current biology : CB · 2012Article
- Total recall. Reconsolidation theory unifies cognitive psychology and neuroscience and creates new therapeutic options for memory-related disorders.EMBO reports · 2011Article
- Aversive olfactory learning and associative long-term memory in Caenorhabditis elegans.Learning & memory (Cold Spring Harbor, N.Y.) · 2011Article
- Chemical modulation of memory formation in larval zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Review
- The sensitivity of memory consolidation and reconsolidation to inhibitors of protein synthesis and kinases: computational analysis.Learning & memory (Cold Spring Harbor, N.Y.) · 2010Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been reported that consolidated memories can return to a labile state when reactivated and undergo a process of re-storage, termed reconsolidation, required for later recall. We investigated memory for a nonassociative learning task (habituation) and found that memory for this task also undergoes reconsolidation after recall. To investigate reconsolidation, we first demonstrated that adult Caenorhabditis elegans are capable of reliable memory 48 h after habituation training (p < 0.05). When heat shock was administered immediately after a reminder, response magnitudes of trained animals matched response levels of untrained animals: the inhibitory effects of heat shock on protein synthesis disrupted memory reconsolidation. Pharmacological blockade of non-NMDA-type glutamate receptors during reminder also eliminated 48 h retention. When expression levels of a specific glutamate receptor subunit (GLR-1) (40% homology to mammalian AMPA-type glutamate receptors) (Hart et al., 1995; Maricq et al., 1995) were measured 48 h after training, there was a significant decrease in trained compared with untrained controls. If trained worms were given a reminder followed immediately by heat shock, the effect of training on GLR-1 levels was reversed. From these studies, we conclude that both the behavioral expression of long-term memory for habituation and a cellular correlate of that memory (the alteration in expression levels of GLR-1) in C. elegans can be altered after retrieval. Furthermore, conditions that impair memory consolidation similarly disrupt memory reconsolidation, suggesting that similar mechanisms are involved.
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