ArticleJournal of clinical microbiology2007
IS1301 fingerprint analysis of Neisseria meningitidis strains belonging to the ET-15 clone.
Article in Journal of clinical microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Emergence of a newProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Pericarditis Caused by Hyperinvasive Strain of Neisseria meningitidis, Sardinia, Italy, 2015.Emerging infectious diseases · 2016Article
- Evolutionary Events Associated with an Outbreak of Meningococcal Disease in Men Who Have Sex with Men.PloS one · 2016Article
- Genomic resolution of an aggressive, widespread, diverse and expanding meningococcal serogroup B, C and W lineage.The Journal of infection · 2015Article
- Article
- Genomic comparative analysis and gene function prediction in infectious diseases: application to the investigation of a meningitis outbreak.BMC infectious diseases · 2013Article
- Article
- Molecular characterization of invasive Neisseria meningitidis strains isolated in Chile during 2010-2011.PloS one · 2013Article
- Resolution of a meningococcal disease outbreak from whole-genome sequence data with rapid Web-based analysis methods.Journal of clinical microbiology · 2012Article
- Ion torrent personal genome machine sequencing for genomic typing of Neisseria meningitidis for rapid determination of multiple layers of typing information.Journal of clinical microbiology · 2012Article
- Neisseria meningitidis adhesin NadA targets beta1 integrins: functional similarity to Yersinia invasin.The Journal of biological chemistry · 2011Article
- Vaccine development against Neisseria meningitidis.Microbial biotechnology · 2011Review
- Characterization of fHbp, nhba (gna2132), nadA, porA, sequence type (ST), and genomic presence of IS1301 in group B meningococcal ST269 clonal complex isolates from England and Wales.Journal of clinical microbiology · 2009Article
- A generic mechanism in Neisseria meningitidis for enhanced resistance against bactericidal antibodies.The Journal of experimental medicine · 2008Article
- Deletion of the meningococcal fetA gene used for antigen sequence typing of invasive and commensal isolates from Germany: frequencies and mechanisms.Journal of clinical microbiology · 2007Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Meningococci of the ET-15 clone frequently cause clusters of invasive meningococcal disease (IMD) and are associated with a high case-fatality ratio. Timely typing of strains from outbreaks of IMD caused by this clone is hampered by the low variability of its surface antigens. We present a new Southern blot-based typing method for ET-15 meningococci based on the insertion element IS1301, which was present in all 70 ET-15 strains tested. Fingerprints were stable in vitro over a period of 100 days of cultivation on agar plates. The discriminatory power of IS1301 fingerprinting exceeded that of typing by serogrouping and antigen sequencing of the outer membrane proteins PorA and FetA, as determined by the analysis of 52 epidemiologically unrelated strains. In addition, the method provided conclusive results with regard to the comparison of strains from clusters of IMD. The investigation of insertion sites of IS1301 revealed several new intragenic insertions, among others, into open reading frames homologous to mafB and tspB. A previously described insertion in nadA was present in more than two-thirds of the strains analyzed, suggesting that NadA is probably an unreliable vaccine candidate for the prevention of ET-15 disease.
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