ArticleMechanisms of ageing and development2006
Tissue specific and non-specific changes in gene expression by aging and by early stage CR.
Article in Mechanisms of ageing and development, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Ageing transcriptome meta-analysis reveals similarities and differences between key mammalian tissues.Aging · 2021Pooled it
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- Expression of RING Finger Protein 38 in Serotonergic Neurons in the Brain of Nile Tilapia,Frontiers in neuroanatomy · 2018Article
- Aging as an Epigenetic Phenomenon.Current genomics · 2017Review
- RING Finger Protein 38 Is a Neuronal Protein in the Brain of Nile Tilapia,Frontiers in neuroanatomy · 2017Article
- Whole-transcriptome analysis of mouse adipose tissue in response to short-term caloric restriction.Molecular genetics and genomics : MGG · 2016Article
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- Effects of Sirt1 on DNA methylation and expression of genes affected by dietary restriction.Age (Dordrecht, Netherlands) · 2013Article
- Biological aging alters circadian mechanisms in murine adipose tissue depots.Age (Dordrecht, Netherlands) · 2013Article
- Analysis of nonlinear gene expression progression reveals extensive pathway and age-specific transitions in aging human brains.PloS one · 2013Article
- Long-term restricted feeding alters circadian expression and reduces the level of inflammatory and disease markers.Journal of cellular and molecular medicine · 2011Article
- δ-Tocotrienol and quercetin reduce serum levels of nitric oxide and lipid parameters in female chickens.Lipids in health and disease · 2011Article
- Article
- Aging: Dial M for Mitochondria.Aging · 2010Review
- Genes and gene expression modules associated with caloric restriction and aging in the laboratory mouse.BMC genomics · 2009Article
- Activation of the immune response is a key feature of aging in mice.Biogerontology · 2009Article
- Age-related transcriptional changes in gene expression in different organs of mice support the metabolic stability theory of aging.Biogerontology · 2009Article
- Calorie restriction and the exercise of chromatin.Genes & development · 2009Review
- Short-term calorie restriction in male mice feminizes gene expression and alters key regulators of conserved aging regulatory pathways.PloS one · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Aging alters the expression of a variety of genes. Calorie restriction (CR), which extends life span in laboratory rodents, also changes gene expression. This study investigated changes in gene expression across three different tissues from the same mouse to examine how aging and early stage CR influence gene expression in different tissues of an organism. Expression profiling of heart, liver, and hypothalamus tissues was done in young (4-6 months) ad libitum fed (AL), young CR (2.5-4.5 months of CR), and old (26-28 months) AL male C57BL/6 mice. Aging significantly altered the expressions of 309, 1819, and 1085 genes in heart, liver, and hypothalamus tissues, respectively. In nine genes, aging altered expression across all three tissues although the regulation directions did not agree across all three tissues for some genes. Early stage CR in young mice significantly changed the expressions of 192, 839, and 100 genes in heart, liver, and hypothalamus tissues, respectively, and seven genes altered expression across all three tissues; three were up regulated and four were down regulated. The results of Gene Ontology (GO) Biological Process analysis indicated up regulation of antigen processing/presentation genes by aging and down regulation of stress response genes by early stage CR in all three tissues. The comparison of the results of aging and short term CR studies showed there were 389 genes, 18 GO biological processes, and 20 GO molecular functions in common.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.