Evidence map›Paper›PMID 17092530›Full record

ArticleVirology2007

The SIVmac239 Pr55Gag isoform, SIV p43, suppresses proteolytic cleavage of Pr55Gag.

Michael G Nicholson, Sheila A Barber, Janice E Clements

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Michael G NicholsonDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Sheila A Barber
Janice E Clements
Johns Hopkins Medicine · USJohns Hopkins University · US

Funding

Project 4: Intracellular mechanism of virus persistence in astrocytes/macrophagesP01MH070306 · NIMH · JOHNS HOPKINS UNIVERSITY · PI CLEMENTS, JANICE E · 2004 to 2015
$16.0M
Cellular Mechanisms that Control SIV & Development of PneumoniaR01HL075840 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CLEMENTS, JANICE E. · 2003 to 2007
$2.0M
Glial Cell Inflammatory Mechanisms &CNS RegulationR01NS047984 · NINDS · JOHNS HOPKINS UNIVERSITY · PI CLEMENTS, JANICE E · 2004 to 2008
$1.8M
MOLECULAR PATHOGENESIS OF AIDS RELATED CNS DISEASET32NS007392 · NINDS · JOHNS HOPKINS UNIVERSITY · PI CLEMENTS, JANICE ELLEN · 1995 to 2005
$895k
NHLBI NIH HHS HL75840NHLBI NIH HHS R01 HL075840NIMH NIH HHS MH70306NIMH NIH HHS P01 MH070306NINDS NIH HHS NS07392NINDS NIH HHS NS47984NINDS NIH HHS R01 NS047984NINDS NIH HHS T32 NS007392
6 · The paper itself

Abstract

In human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) the gag gene encodes the precursor polyprotein Pr55Gag, which is cleaved by the viral protease to produce the major structural proteins. Recently, it has been shown that HIV and SIV gag RNAs contain internal ribosome entry sites (IRESs) that mediate translation of Pr55Gag [Pr57Gag in HIV type 2 (HIV-2)] isoforms. Previously, we demonstrated that SIVmac239 p43(-), a mutant that does not express the Pr55Gag isoform, SIV p43, replicates more efficiently than wild-type (WT) SIVmac239 in cell culture. In this study, we characterize SIVmac239 p43(-) virion production and demonstrate that, in the absence of SIV p43, cleavage of Pr55Gag is increased in budded virions, resulting in a higher percentage of mature particles. Additionally, intracellular cleavage of Pr55Gag is increased in SIVmac239 p43(-), suggesting that SIV p43 suppresses premature cleavage of Pr55Gag by the viral protease.

Indexed as

Aspartic Acid EndopeptidasesCell LineDown-RegulationGene Products, gagHumansProtein IsoformsSimian Immunodeficiency VirusVirus ReplicationAspartic Acid EndopeptidasesGene Products, gagProtein Isoformssimian immunodeficiency virus gag p55SIV(mac) proteinase

Identifiers

PMID17092530
PMCPMC1855267
OpenAlexW2048051917

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.