ArticleThe Journal of membrane biology2006
Mefloquine effects on the lens suggest cooperative gating of gap junction channels.
Article in The Journal of membrane biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Role and Posttranslational Regulation of Cx46 Hemichannels and Gap Junction Channels in the Eye Lens.Frontiers in physiology · 2022Review
- Signaling Between TRPV1/TRPV4 and Intracellular Hydrostatic Pressure in the Mouse Lens.Investigative ophthalmology & visual science · 2020Article
- Aquaporin 0 Modulates Lens Gap Junctions in the Presence of Lens-Specific Beaded Filament Proteins.Investigative ophthalmology & visual science · 2017Article
- Fully automated laser ray tracing system to measure changes in the crystalline lens GRIN profile.Biomedical optics express · 2017Article
- Identification and Functional Assessment of Age-Dependent Truncations to Cx46 and Cx50 in the Human Lens.Investigative ophthalmology & visual science · 2016Article
- Structural and functional similarities of calcium homeostasis modulator 1 (CALHM1) ion channel with connexins, pannexins, and innexins.The Journal of biological chemistry · 2013Article
- Lens gap junctions in growth, differentiation, and homeostasis.Physiological reviews · 2010Review
- Gap junction remodeling associated with cholesterol redistribution during fiber cell maturation in the adult chicken lens.Molecular vision · 2009Article
- The effects of GPX-1 knockout on membrane transport and intracellular homeostasis in the lens.The Journal of membrane biology · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Mefloquine (MFQ) selectively blocks exogenously expressed gap junction channels composed of Cx50 but not Cx46. The purpose of the current study was to evaluate MFQ effects on wild-type (WT) mouse lenses that express both Cx50 and Cx46 in their outer shell of differentiating fibers (DFs). Lenses in which Cx46 was knocked into both Cx50 alleles (KI) were used as controls; MFQ had no effect on coupling in these lenses. When WT lenses were exposed to MFQ, the DF coupling conductance decreased significantly, suggesting that Cx50 contributes about 57% of the coupling conductance in DF and Cx46 contributes 43%. Remarkably, in the presence of MFQ, the 43% of the channels that remained open did not gate closed in response to a reduction in pH, whereas in the absence of MFQ, the same pH change caused all the DF channels to gate closed. Since MFQ is a selective blocker of Cx50 channels, it appears that Cx46 channels lack pH-mediated gating in the absence of functional Cx50 channels but are pH-sensitive in the presence of Cx50 channels. These results suggest the two types of channels interact and gate cooperatively.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.