ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2007
The role of nicotinic acetylcholine receptors in the primary reinforcing and reinforcement-enhancing effects of nicotine.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 47 citations in OpenAlex.
- Acute nicotine differentially impacts anticipatory valence- and magnitude-related striatal activity.Biological psychiatry · 2013Trial
- Clinical and preclinical evidence of sex differences in nicotine-induced enhancement of alcohol self-administration.Psychopharmacology · 2026Review
- Effects of nicotinic receptor antagonism on nicotine and THC self-administration in a model of polysubstance use.The international journal of neuropsychopharmacology · 2026Article
- Effects of nicotinic receptor antagonism on nicotine and THC self-administration in a model of polysubstance use.bioRxiv : the preprint server for biology · 2025Article
- Expression of sensitized β2 nAChR subunits in VTA neurons enhances intravenous nicotine self-administration in male rats.Neuropharmacology · 2024Article
- Elucidating the reinforcing effects of nicotine: a tribute to Nadia Chaudhri.Psychopharmacology · 2023Review
- Lack of evidence for positive reinforcing and prosocial effects of MDMA in pair-housed male and female rats.European journal of pharmacology · 2021Article
- Effects of nicotine conditioning history on alcohol and methamphetamine self-administration in rats.Pharmacology, biochemistry, and behavior · 2019Article
- NMDA Receptor-Dependent Cholinergic Modulation of Mesolimbic Dopamine Cell Bodies: Neurochemical and Behavioral Studies.ACS chemical neuroscience · 2019Article
- Adolescent Rats Self-Administer Less Nicotine Than Adults at Low Doses.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2016Article
- Differentiating the primary reinforcing and reinforcement-enhancing effects of varenicline.Psychopharmacology · 2015Article
- Nicotine enhances the expression of a sucrose or cocaine conditioned place preference in adult male rats.Pharmacology, biochemistry, and behavior · 2014Article
- Molecules and circuits involved in nicotine addiction: The many faces of smoking.Neuropharmacology · 2014Review
- Effects of nicotine on olfactogustatory incentives: preference, palatability, and operant choice tests.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2013Article
- Nicotine-, tobacco particulate matter- and methamphetamine-produced locomotor sensitisation in rats.Psychopharmacology · 2013Article
- Potential therapeutic uses of mecamylamine and its stereoisomers.Pharmacology, biochemistry, and behavior · 2013Review
- Prior exposure to THC increases the addictive effects of nicotine in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- The effect of nicotine on sign-tracking and goal-tracking in a Pavlovian conditioned approach paradigm in rats.Psychopharmacology · 2013Article
- Nicotine-induced enhancement of responding for conditioned reinforcement in rats: role of prior nicotine exposure and α4β2 nicotinic receptors.Psychopharmacology · 2013Article
- The role of conditioning history and reinforcer strength in the reinforcement enhancing effects of nicotine in rats.Psychopharmacology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The primary reinforcing effects of nicotine are mediated by the drugs action at central nervous system nicotinic acetylcholine receptors (nAChRs). Although previous studies have demonstrated that nicotine potently enhances responding for non-pharmacological stimuli, the role of nAChRs in this reinforcement-enhancing effect is not known. The two reinforcement-related effects of nicotine can be dissociated in a paradigm that provides concurrent access to drug infusions and a non-pharmacological visual stimulus (VS). The present study characterized the role of nAChRs in the primary reinforcing effect of nicotine and the reinforcement-enhancing effect of nicotine. For rats with access to VS (VS-Only), nicotine (NIC-Only), both reinforcers contingent upon one response (NIC+VS) or both reinforcers contingent upon separate responses (2-Lever), unit dose-response relationships (0, 30, 60, or 90 microg/kg/infusion, free base) were determined over a 22-day acquisition period. Expression of the two reinforcement-related effects of nicotine was manipulated by pharmacological antagonism of nAChRs (1 mg/kg mecamylamine, subcutaneous, 5-min before the session) or by substituting saline for nicotine infusions (ie extinction) over a series of seven test sessions. Unit dose manipulations yielded an inverse dose-response relationship for active lever responding in the NIC+VS group. The dose-response relationships for rats with independent access to each reinforcer (2-Lever group) were relatively flat. For the 2-Lever group, acute mecamylamine challenge blocked the reinforcement-enhancing effects of nicotine, VS-lever responding decreased to basal levels on the first day of mecamylamine treatment or saline substitution (to the level of the VS-Only group). In contrast, nicotine-lever responding decreased gradually over the 7-day testing period (similar to saline extinction). The two reinforcement-related effects of nicotine are mediated by nAChRs but can be dissociated by acute and chronic profiles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.