ArticleNucleic acids research2006
Four plant Dicers mediate viral small RNA biogenesis and DNA virus induced silencing.
Article in Nucleic acids research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 235 papers.
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Who cites it
235 citing papers in PubMed, 484 citations in OpenAlex.
- Advances in Plant Antiviral RNAi: From Host DCLs/RDRs to Diversified Viral Counteracting Strategies.Viruses · 2026Review
- Small RNA mobility and plant virus diseases.Journal of experimental botany · 2026Review
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- Topical Application of Cocktail dsRNA Induces Plant Resistance Against Bean Common Mosaic Virus (BCMV).Applied biochemistry and biotechnology · 2025Article
- Host ecology and phylogeny shape the temporal dynamics of social bee viromes.Nature communications · 2025Article
- Evidence for the replication of a plant rhabdovirus in its arthropod mite vector.Virus research · 2025Article
- Classification of and detection techniques for RNAi-induced effects in GM plants.Frontiers in plant science · 2025Review
- Deep Sequencing Analysis of Virome Components, Viral Gene Expression and Antiviral RNAi Responses inInternational journal of molecular sciences · 2024Article
- Begomoviruses associated with okra yellow vein mosaic disease (OYVMD): diversity, transmission mechanism, and management strategies.Molecular horticulture · 2024Review
- Characterization of Hibiscus Chlorotic Ringspot Virus-Derived vsiRNAs from Infected Hibiscus rosa-sinensis in China.The plant pathology journal · 2024Article
- Evidence for an RNAi-independent role of Arabidopsis DICER-LIKE2 in growth inhibition and basal antiviral resistance.The Plant cell · 2024Article
- Complete genome analysis of a novel narnavirus in sweet viburnum (Viburnum odoratissimum).Archives of virology · 2024Article
- Knockout of SlDCL2b attenuates the resistance of tomato to potato spindle tuber viroid infection.Molecular plant pathology · 2024Article
- Profiling of small RNAs derived from tomato brown rugose fruit virus in infectedFrontiers in microbiology · 2024Article
- A tomato bushy stunt virus-based vector for simultaneous editing and sensing to survey the host antiviral RNA silencing machinery.PNAS nexus · 2024Article
- Transcriptome and small RNAome profiling uncovers how a recombinant begomovirus evades RDRγ-mediated silencing of viral genes and outcompetes its parental virus in mixed infection.PLoS pathogens · 2024Article
- Cannabis Virome Reconstruction and Antiviral RNAi Characterization through Small RNA Sequencing.Plants (Basel, Switzerland) · 2023Article
- DICER-LIKE2 Plays a Crucial Role in Rice Stripe Virus Coat Protein-Mediated Virus Resistance in Arabidopsis.Viruses · 2023Article
175 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Like other eukaryotes, plants use DICER-LIKE (DCL) proteins as the central enzymes of RNA silencing, which regulates gene expression and mediates defense against viruses. But why do plants like Arabidopsis express four DCLs, a diversity unmatched by other kingdoms? Here we show that two nuclear DNA viruses (geminivirus CaLCuV and pararetrovirus CaMV) and a cytoplasmic RNA tobamovirus ORMV are differentially targeted by subsets of DCLs. DNA virus-derived small interfering RNAs (siRNAs) of specific size classes (21, 22 and 24 nt) are produced by all four DCLs, including DCL1, known to process microRNA precursors. Specifically, DCL1 generates 21 nt siRNAs from the CaMV leader region. In contrast, RNA virus infection is mainly affected by DCL4. While the four DCLs are partially redundant for CaLCuV-induced mRNA degradation, DCL4 in conjunction with RDR6 and HEN1 specifically facilitates extensive virus-induced silencing in new growth. Additionally, we show that CaMV infection impairs processing of endogenous RDR6-derived double-stranded RNA, while ORMV prevents HEN1-mediated methylation of small RNA duplexes, suggesting two novel viral strategies of silencing suppression. Our work highlights the complexity of virus interaction with host silencing pathways and suggests that DCL multiplicity helps mediate plant responses to diverse viral infections.
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