ArticleOrphanet journal of rare diseases2006
Mesothelioma mortality in Europe: impact of asbestos consumption and simian virus 40.
Article in Orphanet journal of rare diseases, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 22 citations in OpenAlex.
- Mesothelium and Malignant Mesothelioma.Journal of developmental biology · 2019Review
- The case for a global ban on asbestos.Environmental health perspectives · 2010Article
- Merkel cell polyomavirus is not detected in mesotheliomas.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2010Article
- Regulation of the retinoblastoma proteins by the human herpesviruses.Cell division · 2009Article
- Lung function predicts survival in a cohort of asbestos cement workers.International archives of occupational and environmental health · 2009Article
- Malignant mesothelioma.Orphanet journal of rare diseases · 2008Review
- Polyomaviruses of nonhuman primates: implications for research.Comparative medicine · 2008Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is well established that asbestos is the most important cause of mesothelioma. The role of simian virus 40 (SV40) in mesothelioma development, on the other hand, remains controversial. This potential human oncogene has been introduced into various populations through contaminated polio vaccines. The aim of this study was to investigate whether the possible presence of SV40 in various European countries, as indicated either by molecular genetic evidence or previous exposure to SV40-contaminated vaccines, had any effect on pleural cancer rates in the respective countries.
methodsWe conducted a Medline search that covered the period from January 1969 to August 2005 for reports on the detection of SV40 DNA in human tissue samples. In addition, we collected all available information about the types of polio vaccines that had been used in these European countries and their SV40 contamination status.
resultsOur ecological analysis confirms that pleural cancer mortality in males, but not in females, correlates with the extent of asbestos exposure 25 - 30 years earlier. In contrast, neither the presence of SV40 DNA in tumor samples nor a previous vaccination exposure had any detectable influence on the cancer mortality rate in neither in males (asbestos-corrected rates) nor in females.
conclusionUsing the currently existing data on SV40 prevalence, no association between SV40 prevalence and asbestos-corrected male pleural cancer can be demonstrated.
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