ArticleFolia biologica2006
NORs and their transcription competence during the cell cycle.
Article in Folia biologica, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
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- From Bioinformatic Modeling to Clinical Observation: Potential Implications of Ribosomal RNA Folding inPathogens (Basel, Switzerland) · 2025Article
- Mapping nucleolus-associated chromatin interactions using nucleolus Hi-C reveals pattern of heterochromatin interactions.Nature communications · 2023Article
- Variability of Human rDNA.Cells · 2021Review
- The chromatin landscape of the ribosomal RNA genes in mouse and human.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2019Review
- Cytogenetic instability of chromosomal nucleolar organizer regions (NORs) in cloned mouse L929 fibroblasts.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2019Article
- Reproduction of the FC/DFC units in nucleoli.Nucleus (Austin, Tex.) · 2016Article
- Nucleolar DNA: the host and the guests.Histochemistry and cell biology · 2016Review
- Chicken rRNA Gene Cluster Structure.PloS one · 2016Article
- Chromosomes at Work: Organization of Chromosome Territories in the Interphase Nucleus.Journal of cellular biochemistry · 2016Article
- Non-Random Patterns in the Distribution of NOR-Bearing Chromosome Territories in Human Fibroblasts: A Network Model of Interactions.Journal of cellular physiology · 2015Article
- Conditional inactivation of Upstream Binding Factor reveals its epigenetic functions and the existence of a somatic nucleolar precursor body.PLoS genetics · 2014Article
- Remodeling of three-dimensional organization of the nucleus during terminal keratinocyte differentiation in the epidermis.The Journal of investigative dermatology · 2013Article
- Chromatin position in human HepG2 cells: although being non-random, significantly changed in daughter cells.Journal of structural biology · 2009Article
- Asymmetrical distribution of the transcriptionally competent NORs in mitosis.Journal of structural biology · 2008Article
- Positioning of the NOR-bearing chromosomes in relation to nucleoli in daughter cells after mitosis.Physiological research · 2008Article
- Positioning of NORs and NOR-bearing chromosomes in relation to nucleoli.Journal of structural biology · 2007Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
In human cells ribosomal genes are organized as clusters, NORs, situated on the short arms of acrocentric chromosomes. It was found that essential components of the RNA polymerase I transcription machinery, including UBF, can be detected on some NORs, termed "competent" NORs, during mitosis. The competent NORs are believed to be transcriptionally active during interphase. However, since individual NORs were not observed in the cell nucleus, their interphase status remains unclear. To address this problem, we detected the competent NORs by two commonly used methods, UBF immunofluorescence and silver staining, and combined them with FISH for visualization of rDNA and/or specific chromosomes. We found that the numbers of competent NORs on specific chromosomes were largely conserved in the subsequent cell cycles, with certain NOR-bearing homologues displaying a very stable pattern of competence. Importantly, those and only those NORs that were loaded with UBF incorporated bromo-uridine in metaphase after stimulation with roscovitine and in telophase, suggesting that competent and only competent NORs contain ribosomal genes transcriptionally active during interphase. Applying premature chromosome condensation with calyculin A, we visualized individual NORs in interphase cells, and found the same pattern of competence as observed in the mitotic chromosomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.