ArticleThe American journal of pathology1991
Neuronal and glial properties of a murine transgenic retinoblastoma model.
Article in The American journal of pathology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- Review
- Human embryonic stem cell-derived organoid retinoblastoma reveals a cancerous origin.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Tumor Environment of Retinoblastoma, Intraocular Cancer.Advances in experimental medicine and biology · 2020Article
- Transgenic Models in Retinoblastoma Research.Ocular oncology and pathology · 2015Review
- Optical coherence tomography enables imaging of tumor initiation in the TAg-RB mouse model of retinoblastoma.Molecular vision · 2015Article
- Intravitreal and subconjunctival melphalan for retinoblastoma in transgenic mice.Journal of ophthalmology · 2014Article
- Changes in retinoblastoma cell adhesion associated with optic nerve invasion.Molecular and cellular biology · 2009Article
- Insights from mouse models into human retinoblastoma.Cell division · 2008Article
- Characterization of neural cell lines derived from SV40 large T-induced primitive neuroectodermal tumors.Brain pathology (Zurich, Switzerland) · 1997Article
- Transgenic models of retinoblastoma: what they tell us about its cause and treatment.Transactions of the American Ophthalmological Society · 1994Article
- Expression of the rasT24 oncogene in the ciliary body pigment epithelium and retinal pigment epithelium results in hyperplasia, adenoma, and adenocarcinoma.The American journal of pathology · 1993Article
- Expression of developmentally defined retinal phenotypes in the histogenesis of retinoblastoma.The American journal of pathology · 1992Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Antigenic properties of a murine transgenic model for hereditary retinoblastoma, induced by a chimeric gene coding for Simian virus 40 large T antigen, an oncogene that inactivates the retinoblastoma susceptibility gene product, were studied by immunohistochemistry. All transgenic mice develop bilateral intraocular retinal tumors in the inner nuclear layer with Homer Wright-like rosettes, and one quarter develop midbrain tumors resembling trilateral retinoblastoma. Cell lines TE-1 and TM-1 were established from intraocular and metastatic tumors, respectively. Intraocular tumors reacted with antibodies to neuron-specific enolase and synaptophysin, while vimentin, glial fibrillary acidic, and S-100 proteins were detected only in reactive glia derived from adjacent retina. The midbrain tumors showed weak reactivity to synaptophysin, and they blended with reactive astrocytes positive for glial markers. The tumors were negative for cytokeratins. Finally both derived cell lines expressed synaptophysin and individual neurofilament triplet proteins in immunofluorescence and Western blotting, supporting their essentially neuronal nature. The antigenic profile resembles human retinoblastoma, but differences in morphology and antigen distribution suggest a more close relationship to neurons of the inner nuclear layer than to photoreceptor cells.
Indexed as
Identifiers
1708946PMC1886007W6806380What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.