ArticleVirchows Archiv. A, Pathological anatomy and histopathology1991
Morphological, immunocytochemical and growth characteristics of three human glioblastomas established in vitro.
Article in Virchows Archiv. A, Pathological anatomy and histopathology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
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- Rapid and efficient transfer of the T cell aging marker CD57 from glioblastoma stem cells to CAR T cells.Oncoscience · 2015Article
- Opposing signaling of ROCK1 and ROCK2 determines the switching of substrate specificity and the mode of migration of glioblastoma cells.Molecular neurobiology · 2014Article
- Cell surface area and membrane folding in glioblastoma cell lines differing in PTEN and p53 status.PloS one · 2014Article
- Regulation of IDO activity by oxygen supply: inhibitory effects on antimicrobial and immunoregulatory functions.PloS one · 2013Article
- Article
- Indoleamine 2,3-dioxygenase is involved in defense against Neospora caninum in human and bovine cells.Infection and immunity · 2009Article
- Flow cytometry analysis of neural differentiation markers expression in human glioblastomas may predict their response to chemotherapy.Cellular and molecular neurobiology · 2009Article
- The missing link between indoleamine 2,3-dioxygenase mediated antibacterial and immunoregulatory effects.Journal of cellular and molecular medicine · 2009Article
- Role of indoleamine-2,3-dioxygenase in alpha/beta and gamma interferon-mediated antiviral effects against herpes simplex virus infections.Journal of virology · 2004Article
- NK-lysin and its shortened analog NK-2 exhibit potent activities against Trypanosoma cruzi.Antimicrobial agents and chemotherapy · 2003Article
- Interleukin-1 inhibits gamma interferon-induced bacteriostasis in human uroepithelial cells.Infection and immunity · 1999Article
- Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines.Brain pathology (Zurich, Switzerland) · 1999Article
- Growth inhibition of newly established human glioma cell lines by leukemia inhibitory factor.Journal of neuro-oncology · 1998Article
- Infection with Trypanosoma cruzi selectively upregulates B7-2 molecules on macrophages and enhances their costimulatory activity.Infection and immunity · 1997Article
- Morphologic, immunologic, biochemical, and cytogenetic characteristics of the human glioblastoma-derived cell line, SNB-19.In vitro cellular & developmental biology. Animal · 1995Article
- Establishment of T-helper type 1- and T-helper type 2-like human Toxoplasma antigen-specific T-cell clones.Immunology · 1995Article
- Co-expression of low molecular weight neurofilament protein and glial fibrillary acidic protein in established human glioma cell lines.The American journal of pathology · 1993Article
- Expression of CD15 in tumours of the nervous system.The Histochemical journal · 1992Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The human glioblastoma-derived cell lines 86HG-39, 87HG-28 and 87HG-31, used for the production of monoclonal antibodies (mAbs) against glioma-associated antigens (GAA), were characterized in terms of morphology, growth behaviour, chromosomes and antigen expression. In the primary tumours, differential expression of glial fibrillary acidic protein, S100 protein, Leu-7 and GAA as defined by mAbs MUC 2-39, MUC 2-63 and MUC 8-22 was demonstrated. Receptors for epidermal growth factor (EGFr) and nerve growth factor (NGFr) were found in many cells in short-term cultures, but the transferrin receptor (Tr) was found in only a few cells of 87HG-28. In permanent cell lines, differentiation antigens and EGFr decreased and Tr increased markedly. NGFr and GAA remained stable. Transplantation tumours of 86HG-39 were partly positive for Tr and GAA. Chromosomal analysis revealed that the 86HG-39 and 87HG-28 cell lines had a hypodiploid or diploid stem line with lines in the hypotetraploid to tetraploid region for 50 in vitro passages. The 87HG-31 cell line had chromosomal patterns in the hypotriploid to triploid region. A gain of chromosomes was seen in the groups C7, C8, C10, D14, F19, F20, G21, G22. The variability of antigens in these tumours and especially during long-term cultivation probably reveals an ability to influence the growth of malignant glioma cells via the respective effector molecules.
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