ReviewJournal of mammary gland biology and neoplasia2006
Pubertal mammary gland development: insights from mouse models.
Review in Journal of mammary gland biology and neoplasia, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 96 citations in OpenAlex.
- Role of DCAF8 in Mammary Ductal Elongation and Branching Morphogenesis.Journal of mammary gland biology and neoplasia · 2026Article
- Molecular Regulatory Mechanisms of Mammary Gland Development: A Review.Animals : an open access journal from MDPI · 2025Review
- Inhibition of DHHC9-mediated CD36 palmitoylation lessens high-fat diet (HFD)-induced impairment of pubertal mammary gland development through the JNK-ERK pathway.Cellular & molecular biology letters · 2025Article
- DNA methylation and gene expression changes in mouse mammary tissue during successive lactations: part II - the impact of lactation rank.Epigenetics · 2023Article
- Macrophages maintain mammary stem cell activity and mammary homeostasis via TNF-α-PI3K-Cdk1/Cyclin B1 axis.NPJ Regenerative medicine · 2023Article
- BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models.Nature communications · 2021Article
- The Cellular Organization of the Mammary Gland: Insights From Microscopy.Journal of mammary gland biology and neoplasia · 2021Review
- Nonhuman primate model in mammary gland biology and neoplasia research.Laboratory animal research · 2021Review
- Cross-Talk Between Inflammation and Fibroblast Growth Factor 10 During Organogenesis and Pathogenesis: Lessons Learnt From the Lung and Other Organs.Frontiers in cell and developmental biology · 2021Review
- The health status alters the pituitary function and reproduction of mice in aLife science alliance · 2020Article
- Regulation of the JAK2-STAT5 Pathway by Signaling Molecules in the Mammary Gland.Frontiers in cell and developmental biology · 2020Review
- Cysteine Dioxygenase Regulates the Epithelial Morphogenesis of Mammary Gland via Cysteine Sulfinic Acid.iScience · 2019Article
- Impact of exposure to diesel exhaust during pregnancy on mammary gland development and milk composition in the rabbit.PloS one · 2019Article
- Luminal MCF-12A & myoepithelial-like Hs 578Bst cells form bilayered acini similar to human breast.Future science OA · 2018Article
- Ectodysplasin target gene Fgf20 regulates mammary bud growth and ductal invasion and branching during puberty.Scientific reports · 2017Article
- Atypical chemokine receptor ACKR2 controls branching morphogenesis in the developing mammary gland.Development (Cambridge, England) · 2017Article
- Changes in mammary histology and transcriptome profiles by low-dose exposure to environmental phenols at critical windows of development.Environmental research · 2017Article
- Regeneration of Bovine Mammary Gland in Immunodeficient Mice by Transplantation of Bovine Mammary Epithelial Cells Mixed with Matrigel.International journal of stem cells · 2016Article
- Effects of the Insulin-like Growth Factor Pathway on the Regulation of Mammary Gland Development.Development & reproduction · 2016Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During puberty the mammary gland develops from a rudimentary tree to a branched epithelial network of ducts which can support alveolar development and subsequent milk production during pregnancy and lactation. This process involves growth, proliferation, migration, branching, invasion, apoptosis and above all, tight regulation which allows these processes to take place simultaneously during the course of just a few weeks to create an adult gland. The process is under hormonal control and is thus coordinated with reproductive development. Mouse models, with overexpressed or knocked-out genes, have highlighted a number of pubertal mammary gland phenotypes and given significant insight into the regulatory mechanisms controlling this period of development. Here we review the published findings of the wide range of gene-manipulated mammary mouse models, documenting the common pubertal mammary gland phenotypes observed, and summarizing their contribution to our current understanding of how pubertal mammary gland development occurs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.