ArticleImmunogenetics2006
Individual odortypes: interaction of MHC and background genes.
Article in Immunogenetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- No evidence for a role of MHC class II genotype in the chemical encoding of heterozygosity and relatedness in Antarctic fur seals.Proceedings. Biological sciences · 2024Article
- Feather chemicals contain information about the major histocompatibility complex in a highly scented seabird.Proceedings. Biological sciences · 2022Article
- Lymphocytic Choriomeningitis Virus Alters the Expression of Male Mouse Scent Proteins.Viruses · 2021Article
- Differential attraction in mosquito-human interactions and implications for disease control.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Individual odour signatures that mice learn are shaped by involatile major urinary proteins (MUPs).BMC biology · 2018Article
- Selection on Coding and Regulatory Variation Maintains Individuality in Major Urinary Protein Scent Marks in Wild Mice.PLoS genetics · 2016Article
- The male sex pheromone darcin stimulates hippocampal neurogenesis and cell proliferation in the subventricular zone in female mice.Frontiers in behavioral neuroscience · 2015Article
- Are mammal olfactory signals hiding right under our noses?Die Naturwissenschaften · 2013Review
- Mate choice for genetic compatibility in the house mouse.Ecology and evolution · 2013Article
- Semiochemical compounds of preen secretion reflect genetic make-up in a seabird species.Proceedings. Biological sciences · 2012Article
- Odour signals major histocompatibility complex genotype in an Old World monkey.Proceedings. Biological sciences · 2011Article
- In search of the chemical basis for MHC odourtypes.Proceedings. Biological sciences · 2010Review
- Darcin: a male pheromone that stimulates female memory and sexual attraction to an individual male's odour.BMC biology · 2010Article
- Making progress in genetic kin recognition among vertebrates.Journal of biology · 2010Review
- Decoding an olfactory mechanism of kin recognition and inbreeding avoidance in a primate.BMC evolutionary biology · 2009Article
- Encoding choosiness: female attraction requires prior physical contact with individual male scents in mice.Proceedings. Biological sciences · 2008Article
- Neural computations with mammalian infochemicals.Journal of chemical ecology · 2008Review
- Biochemical individuality reflected in chromatographic, electrophoretic and mass-spectrometric profiles.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2008Review
- Article
- Quantitative analysis of mouse urine volatiles: in search of MHC-dependent differences.PloS one · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genes of the major histocompatibility complex (MHC) influence the urinary odors of mice. Behavioral studies have shown (1) that mice differing only at MHC have distinct urinary odors, suggesting an MHC odor phenotype or odortype; (2) that the MHC odortype can be recognized across different background strains; and (3) that the MHC odortype is not an additive trait. Very little is known about the odorants underlying this behavioral phenotype. We compared urinary volatile profiles of two MHC haplotypes (H2(b) and H2(k)) and their heterozygous cross (H2(b) x H2(k)) for two different background strains (C57BL/6J and BALB/c) using solid phase micro-extraction (SPME) headspace analysis and gas chromatography/mass spectrometry (GC/MS). Both MHC and background genes substantially influence the volatile profile. Of 148 compounds screened, 108 of them significantly differ between the six genotypes. Surprisingly, for numerous compounds, their MHC associations are moderated by background genes (i.e., there is a significant MHC x background interaction effect in the statistical model relating genotype to relative compound concentration). These interactions account for nearly 30% of the total genetic effect on the volatile profile. MHC heterozygosity further extends the odortype diversity. For many compounds, the volatile expression for the heterozygote is more extreme than the expression for either homozygote, suggesting a heterozygous-specific odortype. The remarkable breadth of effects of MHC variation on concentrations of metabolites and the interaction between MHC and other genetic variation implies the existence of as yet unknown processes by which variation in MHC genes gives rise to variation in volatile molecules in body fluids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.