ArticleJournal of human genetics2007
Association and synergistic interaction between promoter variants of the DRD4 gene in Japanese schizophrenics.
Article in Journal of human genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
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- A meta-analysis of data associatingNeuropsychiatric disease and treatment · 2018Article
- Variants in the dopamine-4-receptor gene promoter are not associated with sensation seeking in skiers.PloS one · 2014Article
- Identification of SNP barcode biomarkers for genes associated with facial emotion perception using particle swarm optimization algorithm.Annals of general psychiatry · 2014Article
- Analysis of 94 candidate genes and 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia.The American journal of psychiatry · 2011Article
- Variable number of tandem repeat polymorphisms of DRD4: re-evaluation of selection hypothesis and analysis of association with schizophrenia.European journal of human genetics : EJHG · 2009Article
- Physiogenomic analysis of localized FMRI brain activity in schizophrenia.Annals of biomedical engineering · 2008Article
- Dopamine genes and schizophrenia: case closed or evidence pending?Schizophrenia bulletin · 2007Review
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent association studies suggest that polymorphisms in the promoter and exon 1 upstream region of the dopamine D4 receptor (DRD4) gene play a functional role in the development of common psychiatric illnesses, although there are also conflicting results. In this study, we re-sequenced this region to identify all genomic variants, and tested them for association with schizophrenia. A total of 570 Japanese schizophrenic cases with matched controls were studied by genotyping all identified/validated common polymorphisms (-1106T>C, -906T>C, -809G>A, -616G>C, -521T>C, -376C>T, -291C>T and 12-bp repeat) and a known microsatellite (120-bp tandem duplication) in the upstream region. A single nucleotide polymorphism (SNP) -809G>A in the promoter region was found to be significantly associated with disease (P=0.018 and 0.032 for allelic and genotypic comparisons, respectively), although not surviving after Bonferroni correction. Logistic regression analysis showed that a combination of the four polymorphisms, -809G>A, -616G>C, -291C>T and the 12-bp repeat, conferred a susceptibility to schizophrenia. These results suggest that the upstream variants have a primary functional effect in the etiology of schizophrenia in the Japanese population.
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