ArticleInfection and immunity2007
Bioinformatic identification of tandem repeat antigens of the Leishmania donovani complex.
Article in Infection and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Distinct repeat architecture landscapes in the proteomes of protozoan parasites.NAR genomics and bioinformatics · 2026Article
- Structural and functional insights from detailed computational analysis ofJournal of genetics · 2026Article
- A point-of-care testing assay for clonorchiasis using a EuNPs-CsTR1 fluorescent probe-based immunoassay.PLoS neglected tropical diseases · 2024Article
- Development of a Novel Enzyme-Linked Immunosorbent Assay and Lateral Flow Test System for Improved Serodiagnosis of Visceral Leishmaniasis in Different Areas of Endemicity.Microbiology spectrum · 2023Article
- Current advances in nanodrug delivery systems for malaria prevention and treatment.Discover nano · 2023Review
- The increased presence of repetitive motifs in the KDDR-plus recombinant protein, a kinesin-derived antigen from Leishmania infantum, improves the diagnostic performance of serological tests for human and canine visceral leishmaniasis.PLoS neglected tropical diseases · 2021Article
- Nationwide serological surveillance of non-tsetse-transmitted horse trypanosomoses in Mongolia.Parasite epidemiology and control · 2020Article
- Gene design, optimization of protein expression and preliminary evaluation of a new chimeric protein for the serological diagnosis of both human and canine visceral leishmaniasis.PLoS neglected tropical diseases · 2020Article
- Draft Genome Sequence of Leishmania tarentolae Parrot Tar II, Obtained by Single-Molecule Real-Time Sequencing.Microbiology resource announcements · 2020Article
- Isolation and characterisation of Leishmania donovani protein antigens from urine of visceral leishmaniasis patients.PloS one · 2020Article
- Photo-cleavable purification/protection handle assisted synthesis of giant modified proteins with tandem repeats.Chemical science · 2019Article
- Refining wet lab experiments with in silico searches: A rational quest for diagnostic peptides in visceral leishmaniasis.PLoS neglected tropical diseases · 2019Article
- Article
- The utility of an rTeGM6-4r-based immunochromatographic test for the serological diagnosis of non-tsetse-transmitted equine trypanosomosis in rural areas of Mongolia.Parasitology research · 2018Article
- Cs1, a Clonorchis sinensis-derived serodiagnostic antigen containing tandem repeats and a signal peptide.PLoS neglected tropical diseases · 2018Article
- Understanding Leishmania parasites through proteomics and implications for the clinic.Expert review of proteomics · 2018Review
- Evaluation of a new set of recombinant antigens for the serological diagnosis of human and canine visceral leishmaniasis.PloS one · 2017Article
- The C-terminal region of Trypanosoma cruzi MASPs is antigenic and secreted via exovesicles.Scientific reports · 2016Article
- Accurate Serodetection of Asymptomatic Leishmania donovani Infection by Use of Defined Antigens.Journal of clinical microbiology · 2016Article
- Identification and Analysis of Immunodominant Antigens for ELISA-Based Detection of Theileria annulata.PloS one · 2016Article
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3 authors.
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Abstract
With large amounts of parasite gene sequence available, additional bioinformatic tools to screen these sequences for identifying genes encoding antigens are needed. Proteins containing tandem repeat (TR) domains are often B-cell antigens, and antibody responses toward TR domains of the proteins are dominant in human infected with certain parasites. We hypothesized that antigens of serological significance could be identified with a search for TR domains. Here we show the result of bioinformatic screening of the gene sequence database of the parasitic protozoan Leishmania infantum. Of 8,191 genes scanned, 64 genes contained TR domains. Of the 64 genes, 22 encoded previously characterized antigens; the remaining 42 genes were previously uncharacterized. By using sera from Sudanese visceral leishmaniasis patients, we confirmed that the TR domains of LinJ11.0070, LinJ25.1100, LinJ27.0400, and LinJ29.0110, which were from the 42 uncharacterized proteins, are also antigenic. The results suggest the validity of this approach for identifying leishmanial antigens of serological significance.
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