ArticleInfection and immunity2007
A mycobacterial gene involved in synthesis of an outer cell envelope lipid is a key factor in prevention of phagosome maturation.
Article in Infection and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Review
- Nontuberculous Mycobacteria, Macrophages, and Host Innate Immune Response.Infection and immunity · 2021Review
- ZnmBio · 2021Article
- MAV_4644 Interaction with the Host Cathepsin Z ProtectsMicroorganisms · 2019Article
- Diversion of phagosome trafficking by pathogenic Rhodococcus equi depends on mycolic acid chain length.Cellular microbiology · 2013Article
- Mycobacterium tuberculosis: success through dormancy.FEMS microbiology reviews · 2012Review
- Identification of a novel gene product that promotes survival of Mycobacterium smegmatis in macrophages.PloS one · 2012Article
- Imatinib-sensitive tyrosine kinases regulate mycobacterial pathogenesis and represent therapeutic targets against tuberculosis.Cell host & microbe · 2011Article
- Mycobacterium tuberculosis and the intimate discourse of a chronic infection.Immunological reviews · 2011Review
- Mycobacterium tuberculosis wears what it eats.Cell host & microbe · 2010Review
- Autophagy, an immunologic magic bullet: Mycobacterium tuberculosis phagosome maturation block and how to bypass it.Future microbiology · 2008Review
- Use of gene dosage effects for a whole-genome screen to identify Mycobacterium marinum macrophage infection loci.Infection and immunity · 2008Article
- The Delta fbpA mutant derived from Mycobacterium tuberculosis H37Rv has an enhanced susceptibility to intracellular antimicrobial oxidative mechanisms, undergoes limited phagosome maturation and activates macrophages and dendritic cells.Cellular microbiology · 2008Article
- Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis.Genome research · 2008Article
- Molecular mechanisms of host-pathogen interactions and their potential for the discovery of new drug targets.Current drug targets · 2008Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Virulent mycobacteria cause arrest of phagosome maturation as a part of their survival strategy in hosts. This process is mediated through multiple virulence factors, whose molecular nature remains elusive. Using Mycobacterium marinum as a model, we performed a genome-wide screen to identify mutants whose ability to inhibit phagosome maturation was impaired, and we succeeded in isolating a comprehensive set of mutants that were not able to occupy an early endosome-like phagosomal compartment in mammalian macrophages. Categorizing and ordering the multiple mutations according to their gene families demonstrated that the genes modulating the cell envelope are the principal factors in arresting phagosome maturation. In particular, we identified a novel gene, pmiA, which is capable of influencing the constitution of the cell envelope lipids, thereby leading to the phagosome maturation block. The pmiA mutant was not able to resist phagosome maturation and was severely attenuated in mice. Complementing the mutant with the wild-type gene restored the attenuated virulence to wild-type levels in mice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.