ArticleThe Journal of biological chemistry2006
G protein-coupled receptor (GPCR) kinase 2 regulates agonist-independent Gq/11 signaling from the mouse cytomegalovirus GPCR M33.
Article in The Journal of biological chemistry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- The human cytomegalovirus vGPCR UL33 is essential for efficient lytic replication in epithelial cells.Journal of virology · 2026Article
- Activation of cytomegalovirus-encoded G protein-coupled receptor UL33 by an innate N-terminal peptide.Communications biology · 2026Article
- Control of GαScience advances · 2022Article
- The Mouse Cytomegalovirus G Protein-Coupled Receptor Homolog, M33, Coordinates Key Features ofJournal of virology · 2022Article
- CMV-encoded GPCR pUL33 activates CREB and facilitates its recruitment to the MIE locus for efficient viral reactivation.Journal of cell science · 2021Article
- Methods for Studying the Function of Cytomegalovirus GPCRs.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Roles of GP33, a guinea pig cytomegalovirus-encoded G protein-coupled receptor homolog, in cellular signaling, viral growth and inflammation in vitro and in vivo.PLoS pathogens · 2018Article
- US28: HCMV's Swiss Army Knife.Viruses · 2018Review
- Murine cytomegalovirus degrades MHC class II to colonize the salivary glands.PLoS pathogens · 2018Article
- Article
- US28, a Virally-Encoded GPCR as an Antiviral Target for Human Cytomegalovirus Infection.Biomolecules & therapeutics · 2017Review
- The M33 G protein-coupled receptor encoded by murine cytomegalovirus is dispensable for hematogenous dissemination but is required for growth within the salivary gland.Journal of virology · 2014Article
- Different classes of antibiotics differentially influence shiga toxin production.Antimicrobial agents and chemotherapy · 2010Article
- Glycan encapsulated gold nanoparticles selectively inhibit shiga toxins 1 and 2.Bioconjugate chemistry · 2010Article
- Human Cytomegalovirus US28: a functionally selective chemokine binding receptor.Infectious disorders drug targets · 2009Review
- Activation of intracellular signaling pathways by the murine cytomegalovirus G protein-coupled receptor M33 occurs via PLC-{beta}/PKC-dependent and -independent mechanisms.Journal of virology · 2009Article
- Feeling manipulated: cytomegalovirus immune manipulation.Virology journal · 2009Article
- M3 muscarinic acetylcholine receptor-mediated signaling is regulated by distinct mechanisms.Molecular pharmacology · 2008Article
- Laboratory strains of murine cytomegalovirus are genetically similar to but phenotypically distinct from wild strains of virus.Journal of virology · 2008Article
- Structure, function and physiological consequences of virally encoded chemokine seven transmembrane receptors.British journal of pharmacology · 2008Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The mouse cytomegalovirus M33 protein is highly homologous to mammalian G protein-coupled receptors (GPCRs) yet functions in an agonist-independent manner to activate a number of classical GPCR signal transduction pathways. M33 is functionally similar to the human cytomegalovirus-encoded US28 GPCR in its ability to induce inositol phosphate accumulation, activate NF-kappaB, and promote smooth muscle cell migration. This ability to promote cellular migration suggests a role for viral GPCRs like M33 in viral dissemination in vivo, and accordingly, M33 is required for efficient murine cytomegalovirus replication in the mouse. Although previous studies have identified several M33-induced signaling pathways, little is known regarding the membrane-proximal events involved in signaling and regulation of this receptor. In this study, we used recombinant retroviruses to express M33 in wild-type and Galpha(q/11)(-/-) mouse embryonic fibroblasts and show that M33 couples directly to the G(q/11) signaling pathway to induce high levels of total inositol phosphates in an agonist-independent manner. Our data also show that GRK2 is a potent regulator of M33-induced G(q/11) signaling through its ability to phosphorylate M33 and sequester Galpha(q/11) proteins. Taken together, the results from this study provide the first genetic evidence of a viral GPCR coupling to a specific G protein signaling pathway as well as identify the first viral GPCR to be regulated specifically by both the catalytic activity of the GRK2 kinase domain and the Galpha(q/11) binding activity of the GRK2 RH domain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.