ArticleHistochemistry1991
Immunohistochemical identification of tubular segments in percutaneous renal biopsies.
Article in Histochemistry, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Validation of Freshly Isolated Rat Renal Cells as a Tool for Preclinical Assessment of Radiolabeled Receptor-Specific Peptide Uptake in the Kidney.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Identification and classification of epithelial cells in nephron segments by actin cytoskeleton patterns.The FEBS journal · 2020Article
- JunD protects against chronic kidney disease by regulating paracrine mitogens.The Journal of clinical investigation · 2003Article
- Role of atrophic tubules in development of interstitial fibrosis in microembolism-induced renal failure in rat.The American journal of pathology · 2001Article
- Possible involvement of myofibroblasts in cellular recovery of uranyl acetate-induced acute renal failure in rats.The American journal of pathology · 2000Article
- A rat model of progressive chronic renal failure produced by microembolism.The American journal of pathology · 1999Article
- Comparison of the morphology of renal cysts and cystic renal tumors.Pathology oncology research : POR · 1997Article
- The distal nephron is preferentially infiltrated by inflammatory cells in acute interstitial nephritis.Virchows Archiv. A, Pathological anatomy and histopathology · 1992Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To identify the renal cortical tubular segments involved in tubulo-interstitial disease in formalin-fixed, paraffin-embedded percutaneous kidney biopsies, we developed multiple immunolabeling protocols using segment-specific tubular markers. The present study of biopsies from patients with minimal change or thin basement membrane nephropathy provides a baseline for interpretation of histopathology. Proximal tubules were stained either by the PAS reaction or by the biotinylated Phaseolus vulgaris erythroagglutinin (PHA-E)-streptavidin-gold-silver system (brush borders black). The anti-Tamm-Horsfall (THP) antibody-immunoperoxidase (aminoethylcarbazole, AEC-IPO), and anti-epidermal cytokeratins (ECK) antibodies-immunoalkaline-Fast Blue BB methods marked the distal straight tubules and the cortical collecting system red-brown and blue, respectively. When these immunolabelings were combined, the coapplication of AEC-PO-labeled peanut agglutinin (PNA) or anti-epithelial membrane antigen antibody-AEC-IPO technique (both are markers for distal nephron) visualized the apical membranes of distal convoluted tubules. In the protocol PHA-E + PNA + THP + ECK, the tubular basement membranes were outlined by the anti-laminin antibody-AEC-IPO staining, carried out simultaneously. The protocol PNA + THP + ECK + PAS was found to be quite appropriate multiple immunolabeling method for the tubules, and is recommended for use as a tool in the study of tubulo-interstitial diseases.
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