ArticleThe EMBO journal1991
Properties of promoter regions of mdg1 Drosophila retrotransposon indicate that it belongs to a specific class of promoters.
Article in The EMBO journal, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Biology ofCurrent genomics · 2018Article
- The Trypanosomatid Pr77-hallmark contains a downstream core promoter element essential for transcription activity of the Trypanosoma cruzi L1Tc retrotransposon.BMC genomics · 2016Article
- Antisense Transcription of Retrotransposons in Drosophila: An Origin of Endogenous Small Interfering RNA Precursors.Genetics · 2016Article
- The L1Tc non-LTR retrotransposon of Trypanosoma cruzi contains an internal RNA-pol II-dependent promoter that strongly activates gene transcription and generates unspliced transcripts.Nucleic acids research · 2007Article
- Identification of multiple transcription initiation, polyadenylation, and splice sites in the Drosophila melanogaster TART family of telomeric retrotransposons.Nucleic acids research · 2006Article
- The initiator element of the Drosophila beta2 tubulin gene core promoter contributes to gene expression in vivo but is not required for male germ-cell specific expression.Nucleic acids research · 2000Article
- Woot, an active gypsy-class retrotransposon in the flour beetle, Tribolium castaneum, is associated with a recent mutation.Genetics · 1996Article
- Transcription of gypsy elements in a Y-chromosome male fertility gene of Drosophila hydei.Genetics · 1996Article
- Complex patterns of transcription of a Drosophila retrotransposon in vivo and in vitro by RNA polymerases II and III.Nucleic acids research · 1995Article
- Features of the hmg 1 subfamily of genes encoding HMG-CoA reductase in potato.Plant molecular biology · 1995Article
- Article
- High transposition rates of Osvaldo, a new Drosophila buzzatii retrotransposon.Molecular & general genetics : MGG · 1994Article
- Degenerating gypsy retrotransposons in a male fertility gene on the Y chromosome of Drosophila hydei.Journal of molecular evolution · 1994Article
- Conserved cis-elements bind a protein complex that regulates Drosophila ras2/rop bidirectional expression.British journal of cancer · 1994Article
- LINE-related elements in Drosophila melanogaster.Genetica · 1994Review
- Structural features of mag, a gypsy-like retrotransposon of Bombyx mori, with unusual short terminal repeats.Genetica · 1994Article
- The Drosophila copia retrotransposon contains binding sites for transcriptional regulation by homeoproteins.Nucleic acids research · 1993Article
- Two subfamilies of MDG1 retrotransposon with different evolutionary histories in D. melanogaster.Journal of molecular evolution · 1993Article
- Aurora, a non-mobile retrotransposon in Drosophila melanogaster heterochromatin.Molecular & general genetics : MGG · 1993Article
- Mutations in the Drosophila gene encoding ribosomal protein S6 cause tissue overgrowth.Molecular and cellular biology · 1993Article
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2 authors.
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Abstract
A sequence 30 bp downstream from the start site of the Drosophila melanogaster retrotransposon mdg1 is shown to be responsible for correct and precise initiation of mdg1 RNA synthesis in combination with the RNA start-site sequence TCAGTT. A sequence-specific DNA binding protein is demonstrated to interact with the +30 sequence, and the efficient binding of this factor is necessary for in vivo transcriptional activity of the plasmid constructs containing mdg1 promoter fragments. The nucleotides -8/+34 of mdg1 represent a minimal promoter which is able to provide correct initiation of transcription by RNA polymerase II at basal levels. A comparison with properties of some other retrotransposable elements and several developmentally regulated cellular genes allows us to conclude that together they form a specific class of RNA polymerase II promoter. This promoter class characteristically lacks upstream sequences necessary for transcription initiation, such as TATA boxes, but requires a specific downstream promoter element within 40 bp downstream of the RNA start site. The level of transcription can, however, be modulated by upstream regulatory elements. The identified sequence-specific downstream initiation factor may be responsible for transcription initiation on promoters of some genes which belong to this class.
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