ArticleApplied optics2006
Tomographic imaging of oxygen by phosphorescence lifetime.
Article in Applied optics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 68 citations in OpenAlex.
- Oxygels: Tunable Phosphorescent Hydrogels for Cherenkov-Excited Luminescence Imaging (CELI) of Oxygen.Advanced healthcare materials · 2026Article
- Simultaneous Probing of Metabolism and Oxygenation of Tumors In Vivo Using FLIM of NAD(P)H and PLIM of a New Polymeric Ir(III) Oxygen Sensor.International journal of molecular sciences · 2022Article
- Ultrafast Tracking of Oxygen Dynamics During Proton FLASH.International journal of radiation oncology, biology, physics · 2022Article
- Biological validation of electron paramagnetic resonance (EPR) image oxygen thresholds in tissue.The Journal of physiology · 2021Review
- Mapping OScientific reports · 2020Article
- Tissue pONature communications · 2020Article
- Multi-beam scan analysis with a clinical LINAC for high resolution Cherenkov-excited molecular luminescence imaging in tissue.Biomedical optics express · 2018Article
- Tomographic phosphorescence lifetime multiplexing.Optics letters · 2018Article
- Water-soluble cyclometalated platinum(ii) and iridium(iii) complexes: synthesis, tuning of the photophysical properties, andRSC advances · 2018Article
- Imaging oxygen in neural cell and tissue models by means of anionic cell-permeable phosphorescent nanoparticles.Cellular and molecular life sciences : CMLS · 2015Article
- Non-invasive transdermal two-dimensional mapping of cutaneous oxygenation with a rapid-drying liquid bandage.Biomedical optics express · 2014Article
- Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota.Gastroenterology · 2014Article
- Cherenkov excited phosphorescence-based pO2 estimation during multi-beam radiation therapy: phantom and simulation studies.Physics in medicine and biology · 2014Article
- Imaging tumor hypoxia to advance radiation oncology.Antioxidants & redox signaling · 2014Review
- Two-photon antenna-core oxygen probe with enhanced performance.Analytical chemistry · 2014Article
- Oxygen tomography by Čerenkov-excited phosphorescence during external beam irradiation.Journal of biomedical optics · 2013Article
- Generation of phosphorescent triplet states via photoinduced electron transfer: energy and electron transfer dynamics in Pt porphyrin-Rhodamine B dyads.The journal of physical chemistry. A · 2012Article
- Using in-vivo fluorescence imaging in personalized cancer diagnostics and therapy, an image and treat paradigm.Technology in cancer research & treatment · 2011Review
- Two new "protected" oxyphors for biological oximetry: properties and application in tumor imaging.Analytical chemistry · 2011Article
- Evaluation of phototoxicity of dendritic porphyrin-based phosphorescent oxygen probes: an in vitro study.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2011Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Imaging of oxygen in tissue in three dimensions can be accomplished by using the phosphorescence quenching method in combination with diffuse optical tomography. We experimentally demonstrate the feasibility of tomographic imaging of oxygen by phosphorescence lifetime. Hypoxic phantoms were immersed in a cylinder with scattering solution equilibrated with air. The phantoms and the medium inside the cylinder contained near-infrared phosphorescent probe(s). Phosphorescence at multiple boundary sites was registered in the time domain at different delays (t(d)) following the excitation pulse. The duration of the excitation pulse (t(p)) was regulated to optimize the contrast in the images. The reconstructed integral intensity images, corresponding to delays t(d), were fitted exponentially to give the phosphorescence lifetime image, which was converted into the three-dimensional image of oxygen concentrations in the volume. The time-independent diffusion equation and the finite element method were used to model the light transport in the medium. The inverse problem was solved by the recursive maximum entropy method. We provide what we believe to be the first example of oxygen imaging in three dimensions using long-lived phosphorescent probes and establish the potential of these probes for diffuse optical tomography.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.