ArticleApplied and environmental microbiology2007
Evidence that accumulation of mutants in a biofilm reflects natural selection rather than stress-induced adaptive mutation.
Article in Applied and environmental microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Cell wall glycosyltransferase ofInfection and immunity · 2025Article
- How Streptococcus suis escapes antibiotic treatments.Veterinary research · 2022Review
- Parallel Evolution in Streptococcus pneumoniae Biofilms.Genome biology and evolution · 2016Article
- Bacterial sex in dental plaque.Journal of oral microbiology · 2013Article
- Competence-dependent endogenous DNA rearrangement and uptake of extracellular DNA give a natural variant of Streptococcus mutans without biofilm formation.Journal of bacteriology · 2011Article
- Antimicrobial traits of tea- and cranberry-derived polyphenols against Streptococcus mutans.Caries research · 2011Review
- Article
- Comparative evaluation of 0.2% Chlorhexidine Mouthwash, Xylitol Chewing Gum, and Combination of 0.2% Chlorhexidine Mouthwash and Xylitol Chewing Gum on SalivaryInternational journal of clinical pediatric dentistryArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The accumulation of mutant genotypes within a biofilm evokes the controversy over whether the biofilm environment induces adaptive mutation or whether the accumulation can be explained by natural selection. A comparison of the virulence of two strains of the dental pathogen Streptococcus mutans showed that rats infected with one of the strains accumulated a high proportion (average, 22%) of organisms that had undergone a deletion between two contiguous and highly homologous genes. To determine if the accumulation of deletion mutants was due to selection or to an increased mutation rate, accumulations of deletion mutants within in vitro planktonic and biofilm cultures and within rats inoculated with various proportions of deletion organisms were quantified. We report here that natural selection was the primary force behind the accumulation of the deletion mutants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.