Evidence map›Paper›PMID 17085550›Full record

ArticleJournal of bacteriology2007

Expression of the iron-activated nspA and secY genes in Neisseria meningitidis group B by Fur-dependent and -independent mechanisms.

Yazdani B Shaik, Susan Grogan, Michael Davey, Shite Sebastian, Sulip Goswami, Borys Szmigielski, Caroline A Genco

Open access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
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  5. Iron-responsive bacterial small RNAs: variations on a theme.Metallomics : integrated biometal science · 2013
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yazdani B ShaikDepartment of Medicine, Section of Molecular Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
Susan Grogan
Michael Davey
Shite Sebastian
Sulip Goswami
Borys Szmigielski
Caroline A Genco
Boston University · US

Funding

The Gonococcal Fur Regulon: Link to PathogenesisR01AI048611 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GENCO, CAROLINE A · 2001 to 2012
$3.9M
NIAID NIH HHS AI046811NIAID NIH HHS R01 AI048611
6 · The paper itself

Abstract

Our whole-genome microarray studies of Neisseria meningitidis MC58 previously identified a set of 153 genes whose transcription was activated during growth in iron. In this study, Fur-mediated regulation of the iron-activated nspA gene was confirmed, whereas iron-activated regulation of the secY gene was demonstrated to be Fur independent. Analysis of the Fur binding sequences in the nspA gene and an additional iron-activated and Fur-regulated gene identified a hexameric (G/T)ATAAT unit in the operator regions of these genes similar to that observed in Fur- and iron-repressed genes. These studies indicate that the expression of the iron-activated nspA and secY genes in N. meningitidis occur by Fur-dependent and -independent mechanisms, respectively.

Indexed as

Gene Expression Regulation, BacterialBacterial Outer Membrane ProteinsBacterial ProteinsBase SequenceDNA FootprintingElectrophoretic Mobility Shift AssayGene Expression ProfilingGenes, BacterialIronNeisseria meningitidis, Serogroup BOligonucleotide Array Sequence AnalysisOligonucleotidesProtein BindingRepressor ProteinsReverse Transcriptase Polymerase Chain ReactionBacterial Outer Membrane ProteinsBacterial Proteinsferric uptake regulating proteins, bacterialIronNspA protein, NeisseriaOligonucleotidesRepressor Proteins

Identifiers

PMID17085550
PMCPMC1797404
OpenAlexW1973541007

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.