ArticleBiophysical journal2007
Adhesive dynamics simulations of the shear threshold effect for leukocytes.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 81 citations in OpenAlex.
- De novo DNA-based catch bonds.Nature chemistry · 2024Article
- Protein Corona Attenuates the Targeting of Antitumor Sialyl Lewis X-Decorated Liposomes to Vascular Endothelial Cells under Flow Conditions.Pharmaceutics · 2023Article
- Receptor-Ligand Binding: Effect of Mechanical Factors.International journal of molecular sciences · 2023Review
- Neutrophils-From Bone Marrow to First-Line Defense of the Innate Immune System.Frontiers in immunology · 2021Review
- Past, Present, and Future of Affinity-based Cell Separation Technologies.Acta biomaterialia · 2020Review
- Mechanical Model for Catch-Bond-Mediated Cell Adhesion in Shear Flow.International journal of molecular sciences · 2020Article
- Nanoscale Functionalized Particles with Rotation-Controlled Capture in Shear Flow.ACS applied materials & interfaces · 2018Article
- An Experimentally Determined State Diagram for Human CD4Cellular and molecular bioengineering · 2018Article
- Organs on chip approach: a tool to evaluate cancer -immune cells interactions.Scientific reports · 2017Article
- Rolling Adhesion of Schizont Stage Malaria-Infected Red Blood Cells in Shear Flow.Biophysical journal · 2017Article
- Dynamic biochemical tissue analysis detects functional L-selectin ligands on colon cancer tissues.PloS one · 2017Article
- Modeling cytoadhesion of Plasmodium falciparum-infected erythrocytes and leukocytes-common principles and distinctive features.FEBS letters · 2016Review
- Multi-scale biological and physical modelling of the tumour micro-environment.Drug discovery today. Disease models · 2015Article
- Adhesive dynamics.Journal of biomechanical engineering · 2014Review
- Characterization of a hybrid dielectrophoresis and immunocapture microfluidic system for cancer cell capture.Electrophoresis · 2013Article
- Rupture of multiple catch-slip bonds: Two-state two-pathway catch-slip bonds.The European physical journal. E, Soft matter · 2013Article
- Contractile fibers and catch-bond clusters: a biological force sensor?Biophysical journal · 2013Article
- Neutrophil rolling at high shear: flattening, catch bond behavior, tethers and slings.Molecular immunology · 2013Review
- Effect of viscous drag on multiple receptor-ligand bonds rupture force.Colloids and surfaces. B, Biointerfaces · 2012Article
- Effect of viscoelasticity on the analysis of single-molecule force spectroscopy on live cells.Biophysical journal · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many experiments have measured the effect of force on the dissociation of single selectin bonds, but it is not yet clear how the force dependence of molecular dissociation can influence the rolling of cells expressing selectin molecules. Recent experiments using constant-force atomic force microscopy or high-resolution microscopic observations of pause-time distributions of cells in a flow chamber show that for some bonds, the dissociation rate is high at low force and initially decreases with force, indicating a catch bond. As the force continues to increase, the dissociation rate increases again, like a slip bond. It has been proposed that this catch-slip bond leads to the shear threshold effect, in which a certain level of shear rate is required to achieve rolling. We have incorporated a catch-slip dissociation rate into adhesive dynamics simulations of cell rolling. Using a relatively simple model for the shear-controlled association rate for selectin bonds, we were able to recreate characteristics of the shear threshold effect seen most prominently for rolling through L-selectin. The rolling velocity as a function of shear rate showed a minimum near 100 s-1. Furthermore, cells were observed to roll at a shear rate near the threshold, but detach and move more quickly when the shear rate was dropped below the threshold. Finally, using adhesive dynamics, we were able to determine ranges of parameters necessary to see the shear threshold effect in the rolling velocity. In summary, we found through simulation that the catch-slip behavior of selectin bonds can be responsible for the shear threshold effect.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.