ArticleBiophysical journal2007
Receptor-mediated and intrinsic polarization and their interaction in chemotaxing cells.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Mating yeast cells use an intrinsic polarity site to assemble a pheromone-gradient tracking machine.The Journal of cell biology · 2019Article
- Interaction of motility, directional sensing, and polarity modules recreates the behaviors of chemotaxing cells.PLoS computational biology · 2013Article
- A computational model of cell polarization and motility coupling mechanics and biochemistry.Multiscale modeling & simulation : a SIAM interdisciplinary journal · 2011Article
- A comparison of mathematical models for polarization of single eukaryotic cells in response to guided cues.PLoS computational biology · 2011Review
- Accuracy of direct gradient sensing by single cells.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- On the spontaneous emergence of cell polarity.Nature · 2008Article
- Wave-pinning and cell polarity from a bistable reaction-diffusion system.Biophysical journal · 2008Article
- Signaling pathways that control cell migration: models and analysis.Wiley interdisciplinary reviews. Systems biology and medicineReview
- Excitable behavior in amoeboid chemotaxis.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Polarization--the clear and persistent localization of different signaling molecules to opposite ends of the cell-is critical for effective chemotaxis in eukaryotic systems. In many systems, polarization can also occur without an externally imposed chemical gradient. We build a modeling framework to study the relationship between the intrinsic capacity for polarization, and that induced by an external gradient. Working within this framework, we analyze different scenarios for the interaction of these pathways. The models are qualitatively simplified, motivated by known properties of the signaling pathways. We also examine the possible role of nonlinear transitions occurring in the polarization pathways. The modeling framework generates testable predictions regarding the relationship between intrinsic polarization and that induced during chemotaxis, and is the first step toward a systematic analysis of the interaction between these pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.