ArticleDevelopmental biology2007
Regulation of the Drosophila distal antennal determinant spineless.
Article in Developmental biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Single-cell RNA sequencing of mid-to-late stage spider embryos: new insights into spider development.BMC genomics · 2024Article
- CRISPR/Cas9-Mediated Mutagenesis ofInsects · 2023Article
- The pleiotropic functions of Pri smORF peptides synchronize leg development regulators.PLoS genetics · 2023Article
- Temporally dynamic antagonism between transcription and chromatin compaction controls stochastic photoreceptor specification in flies.Developmental cell · 2022Article
- Enhancer evolutionary co-option through shared chromatin accessibility input.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Identification of genomic enhancers through spatial integration of single-cell transcriptomics and epigenomics.Molecular systems biology · 2020Article
- Precise staging of beetle horn formation in Trypoxylus dichotomus reveals the pleiotropic roles of doublesex depending on the spatiotemporal developmental contexts.PLoS genetics · 2019Article
- Specification and Patterning ofJournal of developmental biology · 2018Review
- Allocation of distinct organ fates from a precursor field requires a shift in expression and function of gene regulatory networks.PLoS genetics · 2018Article
- Dual functionality ofGenes & development · 2017Article
- Transcription factor Dlx3 induces aryl hydrocarbon receptor promoter activity.Biochemistry and biophysics reports · 2016Article
- Metamorphic labral axis patterning in the beetle Tribolium castaneum requires multiple upstream, but few downstream, genes in the appendage patterning network.Evolution & development · 2014Article
- Interchromosomal communication coordinates intrinsically stochastic expression between alleles.Science (New York, N.Y.) · 2014Article
- Article
- The evolving role of the aryl hydrocarbon receptor (AHR) in the normophysiology of hematopoiesis.Stem cell reviews and reports · 2012Review
- Drosophila twin spot clones reveal cell division dynamics in regenerating imaginal discs.Developmental biology · 2011Article
- Control of the spineless antennal enhancer: direct repression of antennal target genes by Antennapedia.Developmental biology · 2010Article
- Wings, horns, and butterfly eyespots: how do complex traits evolve?PLoS biology · 2009Article
- The Tribolium spineless ortholog specifies both larval and adult antennal identity.Development genes and evolution · 2009Article
- Loss of spineless function transforms the Tribolium antenna into a thoracic leg with pretarsal, tibiotarsal, and femoral identity.Development genes and evolution · 2009Article
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Authors and funding
3 authors.
Funding
Abstract
The transformation of antenna to leg is a classical model for understanding segmental fate decisions in Drosophila. The spineless (ss) gene encodes a bHLH-PAS transcription factor that plays a key role in specifying the identity of distal antennal segments. In this report, we identify the antennal disc enhancer of ss and then use enhancer-lacZ reporters to work out how ss antennal expression is regulated. The antennal determinants Distal-less (Dll) and homothorax (hth) are key activators of the antennal enhancer. Dll is required continuously and, when present at elevated levels, can activate the enhancer in regions devoid of hth expression. In contrast, homothorax (hth) is required only transiently both for activation of the enhancer and for specification of the aristal portion of the antenna. The antennal enhancer is repressed by cut, which determines its proximal limit of expression, and by ectopic Antennapedia (Antp). Repression by Antp is not mediated by hth, suggesting that ss may be a direct target of Antp. Finally, we show that ss+ is not a purely passive target of its regulators: ss+ partially represses hth in the third antennal segment and lies upstream of Dll in the development of the maxillary palp primordia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.