ArticleJournal of magnetic resonance (San Diego, Calif. : 1997)2007
Sensitivity and resolution enhancement in solid-state NMR spectroscopy of bicelles.
Article in Journal of magnetic resonance (San Diego, Calif. : 1997), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Improving the quality of oriented membrane protein spectra using heat-compensated separated local field experiments.Journal of biomolecular NMR · 2019Article
- Formation of pH-Resistant Monodispersed Polymer-Lipid Nanodiscs.Angewandte Chemie (International ed. in English) · 2018Article
- Article
- Article
- Sensitivity and resolution enhancement of oriented solid-state NMR: application to membrane proteins.Progress in nuclear magnetic resonance spectroscopy · 2013Review
- When detergent meets bilayer: birth and coming of age of lipid bicelles.Progress in nuclear magnetic resonance spectroscopy · 2013Review
- The magic of bicelles lights up membrane protein structure.Chemical reviews · 2012Review
- Use of a copper-chelated lipid speeds up NMR measurements from membrane proteins.Journal of the American Chemical Society · 2010Article
- Comprehensive analysis of lipid dynamics variation with lipid composition and hydration of bicelles using nuclear magnetic resonance (NMR) spectroscopy.Langmuir : the ACS journal of surfaces and colloids · 2009Article
- Induction of negative curvature as a mechanism of cell toxicity by amyloidogenic peptides: the case of islet amyloid polypeptide.Journal of the American Chemical Society · 2009Article
- A low-E magic angle spinning probe for biological solid state NMR at 750 MHz.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2009Article
- High-resolution 1H MAS RFDR NMR of biological membranes.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2009Article
- Bicelle-enabled structural studies on a membrane-associated cytochrome B5 by solid-state MAS NMR spectroscopy.Angewandte Chemie (International ed. in English) · 2008Article
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Authors and funding
4 authors.
Funding
Abstract
Magnetically aligned bicelles are becoming attractive model membranes to investigate the structure, dynamics, geometry, and interaction of membrane-associated peptides and proteins using solution- and solid-state NMR experiments. Recent studies have shown that bicelles are more suitable than mechanically aligned bilayers for multidimensional solid-state NMR experiments. In this work, we describe experimental aspects of the natural abundance (13)C and (14)N NMR spectroscopy of DMPC/DHPC bicelles. In particular, approaches to enhance the sensitivity and resolution and to quantify radio-frequency heating effects are presented. Sensitivity of (13)C detection using single pulse excitation, conventional cross-polarization (CP), ramp-CP, and NOE techniques are compared. Our results suggest that the proton decoupling efficiency of the FLOPSY pulse sequence is better than that of continuous wave decoupling, TPPM, SPINAL, and WALTZ sequences. A simple method of monitoring the water proton chemical shift is demonstrated for the measurement of sample temperature and calibration of the radio-frequency-induced heating in the sample. The possibility of using (14)N experiments on bicelles is also discussed.
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