ArticleJournal of the American Society for Mass Spectrometry2007
Analysis of tear glucose concentration with electrospray ionization mass spectrometry.
Article in Journal of the American Society for Mass Spectrometry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 98 citations in OpenAlex.
- Differential effects of dry eye disorders on metabolomic profile by 1H nuclear magnetic resonance spectroscopy.BioMed research international · 2014Trial
- First clinical evaluation of a new long-term subconjunctival glucose sensor.Journal of diabetes science and technology · 2012Trial
- Chromophoric cerium oxide nanoparticle-loaded sucking disk-type strip sensor for optical measurement of glucose in tear fluid.Biomaterials research · 2023Article
- Review
- Changes in tear glucose and insulin concentrations following an oral glucose tolerance test.Clinical & experimental optometry · 2023Article
- Autohydrolysis Application on Vine Shoots and Grape Stalks to Obtain Extracts Enriched in Xylo-Oligosaccharides and Phenolic Compounds.Molecules (Basel, Switzerland) · 2023Article
- Quantification of tear glucose levels and their correlation with blood glucose levels in dogs.Veterinary medicine and science · 2022Article
- Wearable Smart Contact Lenses for Continual Glucose Monitoring: A Review.Frontiers in medicine · 2022Review
- Sense and Learn: Recent Advances in Wearable Sensing and Machine Learning for Blood Glucose Monitoring and Trend-Detection.Frontiers in bioengineering and biotechnology · 2022Review
- Small-volume detection: platform developments for clinically-relevant applications.Journal of nanobiotechnology · 2021Review
- Association between tear and blood glucose concentrations: Random intercept model adjusted with confounders in tear samples negative for occult blood.Journal of diabetes investigation · 2021Observational
- Preocular sensor system for concurrent monitoring of glucose levels and dry eye syndrome using tear fluids.PloS one · 2020Article
- A Set of Global Metabolomic Biomarker Candidates to Predict the Risk of Dry Eye Disease.Frontiers in cell and developmental biology · 2020Article
- Tear Metabolomics in Dry Eye Disease: A Review.International journal of molecular sciences · 2019Review
- Eyeglasses-based tear biosensing system: Non-invasive detection of alcohol, vitamins and glucose.Biosensors & bioelectronics · 2019Article
- Noninvasive Self-diagnostic Device for Tear Collection and Glucose Measurement.Scientific reports · 2019Article
- Contact-Lens Biosensors.Sensors (Basel, Switzerland) · 2018Review
- Microfluidic Contact Lenses.Small (Weinheim an der Bergstrasse, Germany) · 2018Article
- TFOS DEWS II Tear Film Report.The ocular surface · 2017Review
- A Gelated Colloidal Crystal Attached Lens for Noninvasive Continuous Monitoring of Tear Glucose.Polymers · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We have developed a mass spectrometry-based method that allows one to accurately determine the glucose concentration of tear fluid. We used a 1 microL micro-capillary to collect tear fluid from the tear meniscus with minimal irritation of the eye. We analyzed the 1 muL volume of collected tear fluid with liquid-chromatography electrospray ionization mass spectrometry with the use of D-glucose-6,6-d2 as an internal standard. Repeated measurements and a recovery experiment on pooled, onion-induced tears showed that the analysis of the glucose in tears was precise (4% relative standard deviation) and provided 100% recovery. We found the tear glucose concentration of one fasting nondiabetic subject to be 13 to 51 microM while the onion-induced tear glucose concentration of a different nondiabetic subject to be 211 to 256 microM.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.