ArticleInfection and immunity1991
Monoclonal antibodies to surface antigens of a pathogenic Mycoplasma hominis strain.
Article in Infection and immunity, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Detection of Putative Virulence GenesInternational journal of molecular sciences · 2023Article
- Coupled phase-variable expression and epitope masking of selective surface lipoproteins increase surface phenotypic diversity in Mycoplasma hominis.Infection and immunity · 2001Article
- The adherence-associated lipoprotein P100, encoded by an opp operon structure, functions as the oligopeptide-binding domain OppA of a putative oligopeptide transport system in Mycoplasma hominis.Journal of bacteriology · 1999Article
- Monoclonal antibody E8-18 identifies an integral membrane surface protein unique to Mycoplasma capricolum subsp. capripneumoniae.Clinical and diagnostic laboratory immunology · 1997Article
- Monoclonal antibodies to surface-exposes proteins of Mycoplasma mycoides subsp. mycoides (small-colony strain), which causes contagious bovine pleuropneumonia.Clinical and diagnostic laboratory immunology · 1996Article
- Molecular basis of size and antigenic variation of a Mycoplasma hominis adhesin encoded by divergent vaa genes.Infection and immunity · 1996Article
- Variant colony surface antigenic phenotypes within mycoplasma strain populations: implications for species identification and strain standardization.Journal of clinical microbiology · 1996Article
- Selection of Mycoplasma hominis PG21 deletion mutants by cultivation in the presence of monoclonal antibody 552.Infection and immunity · 1995Article
- Identification and characterization of a Mycoplasma hyopneumoniae adhesin.Infection and immunity · 1995Article
- A 135-kilodalton surface antigen of Mycoplasma hominis PG21 contains multiple directly repeated sequences.Infection and immunity · 1995Article
- Antigen heterogeneity among isolates of Mycoplasma bovis is generated by high-frequency variation of diverse membrane surface proteins.Infection and immunity · 1994Article
- A family of phase- and size-variant membrane surface lipoprotein antigens (Vsps) of Mycoplasma bovis.Infection and immunity · 1994Article
- Identification of serotype 1-, 3-, and 6-specific antigens of Ureaplasma urealyticum by using monoclonal antibodies.Journal of clinical microbiology · 1994Article
- Cytoadhesins of Mycoplasma hominis.Infection and immunity · 1993Article
- Characteristics of Mycoplasma hominis adhesion.Journal of bacteriology · 1993Article
- Molecular cloning of a member of the gene family that encodes pMGA, a hemagglutinin of Mycoplasma gallisepticum.Infection and immunity · 1993Article
- Monoclonal antibody-colony immunoblot method specific for isolation of Pediococcus acidilactici from foods and correlation with pediocin (bacteriocin) production.Applied and environmental microbiology · 1992Article
- Monoclonal antibody specific for Listeria monocytogenes associated with a 66-kilodalton cell surface antigen.Applied and environmental microbiology · 1992Article
- Decreased metabolism and viability of Mycoplasma hominis induced by monoclonal antibody-mediated agglutination.Infection and immunity · 1992Article
- Successive synovial Mycoplasma hominis isolates exhibit apparent antigenic variation.Infection and immunity · 1991Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Three monoclonal antibodies (MAbs) were prepared against an arthritogenic strain of Mycoplasma hominis isolated from the joint aspirates of a patient with chronic septic arthritis. Immunoblots of polyacrylamide gel-electrophoresed proteins before and after surface proteolysis showed that the predominant antigenic determinants were on surface-exposed polypeptides. These polypeptides have extensive hydrophobic characteristics, as demonstrated by Triton X-114 phase partitioning. The electrophoresed proteins from cells grown in medium containing [14C]palmitate were blotted onto nitrocellulose which was both reacted with the MAbs and exposed to X-ray film. Superimposable bands on both the immunoblots and the exposed film suggested that the proteins might be acylated. The MAbs were further tested for reactivity with 16 other strains of M. hominis isolated from patients with septic arthritis (1 strain), septicemia (10 strains), or nongonococcal urethritis (1 strain); from the cervix (1 strain), rectum (1 strain), or surgical wound (1 strain) of patients; and from a contaminated cell culture. No single protein was consistently recognized from strain to strain, although a 94-kDa protein from 16 of the 17 strains tested was bound by at least one of the MAbs. The apparent antigenic heterogeneity among strains of M. hominis, including those isolated from the same tissue source and/or from patients with the same type of clinical disease, might be misleading in that all strains express epitopes associated with a discrete number of proteins to which one, two, or all three MAbs bind. The expression of the epitopes on multiple proteins from the same or different strains may reflect a mechanism for generating antigenic diversity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.