Trial reportClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2006
CD2 identifies a monocyte subpopulation with immunoglobulin E-dependent, high-level expression of Fc epsilon RI.
Trial report in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Modulation of blood inflammatory markers by benralizumab in patients with eosinophilic airway diseases.Respiratory research · 2019Trial
- FcεRI+IgE+ monocytes are linked to atopy and allergic inflammation with distinct phenotypes and enhanced antiviral responses.bioRxiv : the preprint server for biology · 2026Article
- Efficacy of omalizumab in the treatment of STAT3 loss-of-function mutations associated with autosomal dominant hyperimmunoglobulin E syndrome-a case report.Translational pediatrics · 2025Article
- Omalizumab controls surface phenotypes of dendritic cells and monocytes in asthma.The journal of allergy and clinical immunology. Global · 2025Article
- SHIP-1 Differentially Regulates IgE-Induced IL-10 and Antiviral Responses in Human Monocytes.European journal of immunology · 2025Article
- SHIP-1 differentially regulates IgE-induced IL-10 and antiviral responses in human monocytes.bioRxiv : the preprint server for biology · 2024Article
- Review
- Effects of Therapeutic Antibodies on Gene and Protein Signatures in Asthma Patients: A Comparative Systematic Review.Biomedicines · 2022Review
- IgE-Binding Monocytes Have an Enhanced Ability to Produce IL-8 (CXCL8) in Animals with Naturally Occurring Allergy.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- CD2 Regulates Pathogenesis of Asthma Induced by House Dust Mice Extract.Frontiers in immunology · 2020Article
- Phenotype and function of IgE-binding monocytes in equine Culicoides hypersensitivity.PloS one · 2020Article
- Mind the Map: Technology Shapes the Myeloid Cell Space.Frontiers in immunology · 2019Review
- Human Monocyte Heterogeneity as Revealed by High-Dimensional Mass Cytometry.Arteriosclerosis, thrombosis, and vascular biology · 2019Article
- Biological therapies for eosinophilic asthma.Expert opinion on biological therapy · 2018Review
- The role of FcεRI expressed in dendritic cells and monocytes.Cellular and molecular life sciences : CMLS · 2015Review
- IgE cross-linking critically impairs human monocyte function by blocking phagocytosis.The Journal of allergy and clinical immunology · 2013Article
- The role of costimulatory molecules in allergic disease and asthma.International archives of allergy and immunology · 2010Review
- Expression of the high affinity IgE receptor by neutrophils of individuals with allergic asthma is both minimal and insensitive to regulation by serum IgE.Clinical immunology (Orlando, Fla.) · 2009Article
- Anti-immunoglobulin e therapy.The World Allergy Organization journal · 2008Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundFc epsilon RI expression by monocytes can affect monocyte function via multiple mechanisms, thereby potentially influencing the generation of allergic inflammation. Previous studies on the in vivo regulation of monocyte Fc epsilon RI expression by ambient IgE have yielded conflicting results.
objectiveWe hypothesized that monocyte Fc epsilon RI expression is limited to a specific monocyte subset, and that within that subset Fc epsilon RI surface expression is correlated to serum IgE.
methodsStudy 1: Blood was obtained from non-allergic subjects (n=14) and subjects with allergic asthma (n=18), hypereosinophilic syndrome (n=2), hyper-IgE syndrome (n=6), and helminth infection (n=4). Study 2: Blood was obtained from allergic subjects in a clinical trial of omalizumab before and during study drug treatment. Monocyte surface Fc epsilon RI expression was measured using flow cytometry.
resultsFc epsilon RI expression was significantly greater in the CD2(high) vs. CD2(low) monocyte subsets (31% vs. 1.9% median Fc epsilon RI+, respectively). In asthmatic and non-atopic healthy control subjects, CD2(low) monocytes expressed little or undetectable Fc epsilon RI. In study 1, Fc epsilon RI expression was highly correlated to serum IgE in the CD2(high), but not in the CD2(low) monocyte subpopulation (R values of 0.67 and 0.41, respectively). In study 2, omalizumab, but not placebo, caused a significant and sustained decline in Fc epsilon RI expression within the CD2(high) monocyte subset.
conclusionsCD2 defines a monocyte subset with high Fc epsilon RI expression, whose magnitude is highly correlated to serum IgE. As such, this new description of CD2(high) monocytes as Fc epsilon RI-bearing cells suggests that they may be potential targets of anti-IgE immunomodulatory therapies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.