SynthesisPsychopharmacology2007
MDMA use and neurocognition: a meta-analytic review.
Synthesis in Psychopharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cognitive functioning associated with acute and subacute effects of classic psychedelics and MDMA - a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Differential effects of ecstasy on short-term and working memory: a meta-analysis.Neuropsychology review · 2010Pooled it
- Memory-related hippocampal functioning in ecstasy and amphetamine users: a prospective fMRI study.Psychopharmacology · 2013Trial
- Durability of improvement in post-traumatic stress disorder symptoms and absence of harmful effects or drug dependency after 3,4-methylenedioxymethamphetamine-assisted psychotherapy: a prospective long-term follow-up study.Journal of psychopharmacology (Oxford, England) · 2013Trial
- MDMA (ecstasy) effects on actual driving performance before and after sleep deprivation, as function of dose and concentration in blood and oral fluid.Psychopharmacology · 2012Trial
- The acute effects of 3,4-methylenedioxymethamphetamine and d-methamphetamine on human cognitive functioning.Psychopharmacology · 2012Trial
- Altered pain responses in abstinent (±)3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") users.Psychopharmacology · 2011Trial
- Dose-related effects of MDMA on psychomotor function and mood before, during, and after a night of sleep loss.Psychopharmacology · 2010Trial
- Equivalent effects of acute tryptophan depletion on REM sleep in ecstasy users and controls.Psychopharmacology · 2009Trial
- Bupropion improves attention but does not affect impulsive behavior in healthy young adults.Experimental and clinical psychopharmacology · 2008Trial
- Prospective memory impairment in "ecstasy" (MDMA) users.Psychopharmacology · 2007Trial
- Changing Patterns of Recent Substance Use in Emerging Adulthood and Their Associations With Cognitive Functions and Mental Health.Biological psychiatry global open science · 2026Article
- Mental disorders in childhood or adolescence and subsequent comprehensive school achievement.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Subjective and neurocognitive profiling of clinical doses of 3,4-methylenedioxymethamphetamine (MDMA) in healthy volunteers: implications for therapeutic use.Molecular psychiatry · 2026Review
- Something is not nothing: Hair-tested substance use and cognitive functions in a large community sample of young adults.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- The functional connectome of 3,4-methyldioxymethamphetamine-related declarative memory impairments.Human brain mapping · 2023Article
- Brain-derived neurotrophic factor protects serotonergic neurons against 3,4-methylenedioxymethamphetamine ("Ecstasy") induced cytoskeletal damage.Journal of neural transmission (Vienna, Austria : 1996) · 2022Article
- Downregulation of the Vitamin D Receptor Regulated Gene Set in the Hippocampus After MDMA Treatment.Frontiers in pharmacology · 2018Article
- Chronic and recreational use of cocaine is associated with a vulnerability to semantic interference.Psychopharmacology · 2015Article
- Legal highs: staying on top of the flood of novel psychoactive substances.Therapeutic advances in psychopharmacology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
rationaleTo determine the association between MDMA misuse and neurocognition using meta-analysis.
objectiveSeparate analyses were conducted based on two sets of inclusion/exclusion criteria. A relatively stringent set required that the subjects be matched on important moderator variables, whereas the other did not. The study participants' performance in the following neurocognitive domains was reviewed: attention/concentration, verbal and nonverbal learning and memory, psychomotor speed and executive systems functioning.
resultsIn the 11 studies meeting the relatively stringent inclusion/exclusion criteria for this review, MDMA use was associated with neurocognitive deficits in each domain. Similarly, in the 23 studies meeting the relatively lenient inclusion/exclusion criteria for this review, MDMA use was associated with neurocognitive deficits in each domain. Small to medium effect sizes were generally observed. A comparison of the effect sizes across the two sets of analyses did not reveal significant differences.
conclusionsThe findings from this review reveal that MDMA use is associated with neurocognitive deficits. The implications of these findings are discussed.
Indexed as
Identifiers
17082969What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.