ArticleInvertebrate neuroscience : IN2006
Characterization of the Caenorhabditis elegans G protein-coupled serotonin receptors.
Article in Invertebrate neuroscience : IN, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 71 citations in OpenAlex.
- Light sensing enhances thermotolerance and competitive fitness via serotonergic signaling in an eyeless organism.Cell research · 2026Article
- Deciphering the regulatory mechanism of neural behavioral decisions through biogenic amine-mediated modulation of neural circuits inFrontiers in systems neuroscience · 2026Review
- Serotonergic Signaling GovernseNeuro · 2025Article
- Methionine cycle in C. elegans serotonergic neurons regulates diet-dependent behaviour and longevity through neuron-gut signaling.Nature communications · 2025Article
- The hypoxic response extends lifespan through a bioaminergic and peptidergic neural circuit.bioRxiv : the preprint server for biology · 2025Article
- Multiple Subthreshold GPCR Signals Combined by the G-Proteins GαThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Aripiprazole Offsets Mutant ATXN3-Induced Motor Dysfunction by Targeting Dopamine DBiomedicines · 2022Article
- Azepine-Indole Alkaloids FromFrontiers in neuroscience · 2022Article
- Research Advances in Heterotrimeric G-Protein α Subunits and Uncanonical G-Protein Coupled Receptors in Plants.International journal of molecular sciences · 2021Review
- Biogenic amine neurotransmitters promote eicosanoid production and protein homeostasis.EMBO reports · 2021Article
- Cellular Expression and Functional Roles of All 26 Neurotransmitter GPCRs in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Neurotransmitter signaling through heterotrimeric G proteins: insights from studies in C. elegans.WormBook : the online review of C. elegans biology · 2018Review
- Past experience shapes sexually dimorphic neuronal wiring through monoaminergic signalling.Nature · 2018Article
- Antagonistic Serotonergic and Octopaminergic Neural Circuits Mediate Food-Dependent Locomotory Behavior inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 inThe Journal of biological chemistry · 2017Article
- Cancer cells become less deformable and more invasive with activation of β-adrenergic signaling.Journal of cell science · 2016Article
- Article
- Identification of G protein-coupled receptors in Schistosoma haematobium and S. mansoni by comparative genomics.Parasites & vectors · 2014Article
- Serotonergic chemosensory neurons modify the C. elegans immune response by regulating G-protein signaling in epithelial cells.PLoS pathogens · 2013Article
- Serotonin circuits and anxiety: what can invertebrates teach us?Invertebrate neuroscience : IN · 2012Review
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serotonin (5-HT) regulates a wide range of behaviors in Caenorhabditis elegans, including egg laying, male mating, locomotion and pharyngeal pumping. So far, four serotonin receptors have been described in the nematode C. elegans, three of which are G protein-coupled receptors (GPCR), (SER-1, SER-4 and SER-7), and one is an ion channel (MOD-1). By searching the C. elegans genome for additional 5-HT GPCR genes, we identified five further genes which encode putative 5-HT receptors, based on sequence similarities to 5-HT receptors from other species. Using loss-of-function mutants and RNAi, we performed a systematic study of the role of the eight GPCR genes in serotonin-modulated behaviors of C. elegans (F59C12.2, Y22D7AR.13, K02F2.6, C09B7.1, M03F4.3, F16D3.7, T02E9.3, C24A8.1). We also examined their expression patterns. Finally, we tested whether the most likely candidate receptors were able to modulate adenylate cyclase activity in transfected cells in a 5-HT-dependent manner. This paper is the first comprehensive study of G protein-coupled serotonin receptors of C. elegans. It provides a direct comparison of the expression patterns and functional roles for 5-HT receptors in C. elegans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.