ArticleJournal of immunology (Baltimore, Md. : 1950)2006
CD8 T cell recall responses are regulated by the tissue tropism of the memory cell and pathogen.
Article in Journal of immunology (Baltimore, Md. : 1950), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Tissue-Resident Memory T Cells in Skin Diseases: A Systematic Review.International journal of molecular sciences · 2021Pooled it
- scRNA+TCR-seq reveals the pivotal role of dual receptor T lymphocytes in the pathogenesis of Kawasaki disease and during IVIG treatment.Frontiers in immunology · 2024Article
- Early drop of circulating T cells negatively correlates with the protective immune response to Yellow Fever vaccination.Human vaccines & immunotherapeutics · 2020Article
- Delineation of a molecularly distinct terminally differentiated memory CD8 T cell population.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The physiological and pathological roles and applications of sialyl Lewis x, a common carbohydrate ligand of the three selectins.Glycoconjugate journal · 2020Review
- CD4Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Chikungunya virus impairs draining lymph node function by inhibiting HEV-mediated lymphocyte recruitment.JCI insight · 2018Article
- Review
- CD8Frontiers in immunology · 2018Review
- Counting CD4(+) and CD8(+) T cells in the spleen: a novel in vivo method for assessing biomaterial immunotoxicity.Regenerative biomaterials · 2014Article
- Peripheral regulation of T cells by dendritic cells during infection.Immunologic research · 2014Review
- The longevity of memory CD8 T cell responses after repetitive antigen stimulations.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- PD-L1 limits the mucosal CD8+ T cell response to Chlamydia trachomatis.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Celebrating diversity in memory T cells.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Tissue-resident memory T cells.Immunological reviews · 2013Review
- Article
- CD11a regulates effector CD8 T cell differentiation and central memory development in response to infection with Listeria monocytogenes.Infection and immunity · 2013Article
- Peripheral prepositioning and local CXCL9 chemokine-mediated guidance orchestrate rapid memory CD8+ T cell responses in the lymph node.Immunity · 2013Article
- Population dynamics of naive and memory CD8 T cell responses after antigen stimulations in vivo.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- The initial draining lymph node primes the bulk of the CD8 T cell response and influences memory T cell trafficking after a systemic viral infection.PLoS pathogens · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Whether memory CD8 T cells can be reactivated in nonlymphoid tissues is unclear. Using mice lacking the spleen, lymph nodes, or both, we show that the secondary T cell response, but not homeostatic maintenance of memory cells, required lymphoid tissue. Whereas primary and secondary CD8 T cell responses to vesicular stomatitis virus infection were lymph node dependent, responses to Listeria monocytogenes infection were driven primarily in the spleen. Memory cell subset reactivation was also regulated by location of the responding population and the pathogen. Thus, CD62Llow effector memory T cells (TEM) cells responded nearly as well as CD62Lhigh central memory T cells (TCM) and TCM cells after L. monocytogenes infection, and both subsets generated equivalent populations of secondary memory cells. In contrast, TCM cells, but not TEM cells, mounted a robust response to vesicular stomatitis virus infection. TCM and TEM cells also required lymphoid tissue to mount recall responses, and the bone marrow did not contribute significantly to the response of either subset. Our findings indicated that characteristics of the infectious agent and the migratory preferences of memory cells dictated the secondary lymphoid tissue requirement for the recall response to infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.