ArticleAmerican journal of respiratory and critical care medicine2007
Higher urine nitric oxide is associated with improved outcomes in patients with acute lung injury.
Article in American journal of respiratory and critical care medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- A systematic review of biomarkers multivariately associated with acute respiratory distress syndrome development and mortality.Critical care (London, England) · 2020Pooled it
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- Prognostic value of plasma N-terminal probrain natriuretic peptide levels in the acute respiratory distress syndrome.Critical care medicine · 2008Trial
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- Effects of mechanical ventilation on the interstitial extracellular matrix in healthy lungs and lungs affected by acute respiratory distress syndrome: a narrative review.Critical care (London, England) · 2024Review
- Melatonin Suppresses LPS-Induced Oxidative Stress in Dendritic Cells for Inflammatory Regulation via the Nrf2/HO-1 Axis.Antioxidants (Basel, Switzerland) · 2022Article
- Dexamethasone increased the survival rate in Plasmodium berghei-infected mice.Scientific reports · 2021Article
- Prognostic value of plasma mitochondrial DNA in acute respiratory distress syndrome (ARDS): a single-center observational study.Journal of thoracic disease · 2020Article
- Biomarkers for Acute Respiratory Distress syndrome and prospects for personalised medicine.Journal of inflammation (London, England) · 2019Review
- Higher mini-BAL total protein concentration in early ARDS predicts faster resolution of lung injury measured by more ventilator-free days.American journal of physiology. Lung cellular and molecular physiology · 2017Article
- Metabolomics based predictive biomarker model of ARDS: A systemic measure of clinical hypoxemia.PloS one · 2017Article
- Arginine and citrulline and the immune response in sepsis.Nutrients · 2015Review
- Gene expression profiles analysis identifies key genes for acute lung injury in patients with sepsis.Diagnostic pathology · 2014Article
- Thrombocytopenia is associated with acute respiratory distress syndrome mortality: an international study.PloS one · 2014Article
- Statins as a novel therapeutic strategy in acute lung injury.Pulmonary circulation · 2012Article
- Biomarkers in acute lung injury.Translational research : the journal of laboratory and clinical medicine · 2012Review
- Prognostic significance of elevated cardiac troponin-T levels in acute respiratory distress syndrome patients.PloS one · 2012Article
- Therapeutic approaches using nitric oxide in infants and children.Free radical biology & medicine · 2011Review
- NOS2 regulation of LPS-induced airway inflammation via S-nitrosylation of NF-{kappa}B p65.American journal of physiology. Lung cellular and molecular physiology · 2011Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
rationaleNitrogen oxide (NO) species are markers for oxidative stress that may be pathogenic in acute lung injury (ALI).
objectivesWe tested two hypotheses in patients with ALI: (1) higher levels of urine NO would be associated with worse clinical outcomes, and (2) ventilation with lower VT would reduce urine NO as a result of less stretch injury.
methodsUrine NO levels were measured by chemiluminescence in 566 patients enrolled in the National Heart Lung and Blood Institute Acute Respiratory Distress Syndrome Network trial of 6 ml/kg versus 12 ml/kg VT ventilation. The data were expressed corrected and uncorrected for urine creatinine (Cr).
resultsHigher baseline levels of urine NO to Cr were associated with lower mortality (odds ratio, 0.43 per log(10) increase in the ratio), more ventilator-free days (mean increase, 1.9 d), and more organ-failure-free days (mean increase, 2.3 d) on multivariate analysis (p < 0.05 for all analyses). Similar results were obtained using urine NO alone. NO to Cr levels were higher on Day 3 in the 6 ml/kg than in the 12 ml/kg VT group (p = 0.04).
conclusionsContrary to our hypothesis, higher urine NO was associated with improved outcomes in ALI at baseline and after treatment with the 6 ml/kg VT strategy. Higher endogenous NO may reflect less severe lung injury and better preservation of the pulmonary and systemic endothelium or may serve a protective function in patients with ALI.
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