ArticleAmerican journal of respiratory and critical care medicine2007
Coagulation factor Xa modulates airway remodeling in a murine model of asthma.
Article in American journal of respiratory and critical care medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 60 citations in OpenAlex.
- Article
- Dysregulated haemostasis in thrombo-inflammatory disease.Clinical science (London, England : 1979) · 2022Review
- Factor Xa inhibitor, edoxaban ameliorates renal injury after subtotal nephrectomy by reducing epithelial-mesenchymal transition and inflammatory response.Physiological reports · 2022Article
- Imbalanced Coagulation in the Airway of Type-2 High Asthma with Comorbid Obesity.Journal of asthma and allergy · 2021Review
- Active-Ingredient Screening and Synergistic Action Mechanism of Shegan Mixture for Anti-Asthma Effects Based on Network Pharmacology in a Mouse Model of Asthma.Drug design, development and therapy · 2021Article
- Edoxaban Exerts Antioxidant Effects Through FXa Inhibition and Direct Radical-Scavenging Activity.International journal of molecular sciences · 2019Article
- Selective cleavage of fibrinogen by diverse proteinases initiates innate allergic and antifungal immunity through CD11b.The Journal of biological chemistry · 2019Article
- Renoprotective effects of a factor Xa inhibitor: fusion of basic research and a database analysis.Scientific reports · 2018Article
- Are pulmonary hemostasis and fibrinolysis out of balance in equine chronic pneumopathies?Journal of veterinary science · 2017Article
- Chronic Rhinosinusitis and the Coagulation System.Allergy, asthma & immunology research · 2015Review
- Rivaroxaban Induces Mucosal Healing in a Rat Model of Trinitrobenzene Sulfonic Acid-Induced Colitis.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2015Article
- Amphiregulin-dependent mucous cell metaplasia in a model of nonallergic lung injury.American journal of respiratory cell and molecular biology · 2012Article
- Article
- Are mouse models of asthma appropriate for investigating the pathogenesis of airway hyper-responsiveness?Frontiers in physiology · 2012Article
- Chronic allergen challenge induces pulmonary extramedullary hematopoiesis.Experimental lung research · 2011Article
- The endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors.The Journal of biological chemistry · 2011Article
- Protease-activated receptor-2 induces myofibroblast differentiation and tissue factor up-regulation during bleomycin-induced lung injury: potential role in pulmonary fibrosis.The American journal of pathology · 2010Article
- A severe deficiency of coagulation factor VIIa results in attenuation of the asthmatic response in mice.American journal of physiology. Lung cellular and molecular physiology · 2009Article
- Sleep apnea: a proinflammatory disorder that coaggregates with obesity.The Journal of allergy and clinical immunology · 2008Review
- Protease-activated receptor-2 (PAR-2) is a weak enhancer of mucin secretion by human bronchial epithelial cells in vitro.The international journal of biochemistry & cell biology · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
rationalePrevious studies have demonstrated that dysregulated coagulation and fibrinolysis contribute to the pathogenesis of asthma.
objectiveThe role of procoagulant factor X in a murine model of ovalbumin (OVA)-induced asthma was investigated.
methodsBiochemical, cellular, and physiologic in vivo and in vitro approaches were used to determine effects of factor X on the asthmatic response in mice. MEASUREMENTS AND MAIN
resultsFactor X transcript levels and factor Xa activity were increased in lungs of asthmatic mice challenged with OVA, compared with controls treated with phosphate-buffered saline. Factor X was highly expressed in bronchoalveolar lavage fluid macrophages from asthmatic mice. Treatment of mice with the factor Xa inhibitor fondaparinux during the last 4 wk of OVA challenge resulted in the attenuation of airway hyperresponsiveness but did not alter infiltration of inflammatory cells into the lung. There was a significant decrease in the thickness of the mucosal layer and in lung collagen deposition in fondaparinux-treated mice. In vitro investigations using human mucus-producing NCI-H292 cells indicated that exogenous factor Xa enhanced mucin production in a dose-dependent manner. Levels of amphiregulin, a protein that induces mucin production, were also increased in cells stimulated by factor Xa.
conclusionsThe results of this study introduce a novel participant in the asthmatic response and indicate that factor Xa functions in airway remodeling in asthma by stimulating mucin production, through regulation of amphiregulin expression and collagen deposition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.