ArticleStroke2006
Intra- and interrater reliability of ischemic lesion volume measurements on diffusion-weighted, mean transit time and fluid-attenuated inversion recovery MRI.
Article in Stroke, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Does diffusion-weighted imaging represent the ischemic core? An evidence-based systematic review.AJNR. American journal of neuroradiology · 2009Pooled it
- Effect of In-Hospital Remote Ischemic Perconditioning on Brain Infarction Growth and Clinical Outcomes in Patients With Acute Ischemic Stroke: The RESCUE BRAIN Randomized Clinical Trial.JAMA neurology · 2020Trial
- Trial
- Trial
- Hypoperfusion intensity ratio is associated with follow-up infarct volume in medium vessel occlusions: A multicenter multinational study.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- Predictive value of follow-up infarct volume on functional outcomes in middle cerebral artery M2 segment vessel occlusion stroke treated with mechanical thrombectomy.European stroke journal · 2025Article
- Tissue Is the Issue: A Systematic Review of Methods for the Determination of Infarct Volume in Acute Ischaemic Stroke.Brain sciences · 2025Review
- Late Lesion Growth following Endovascular Therapy: Is 24 h Too Early to Assess Acute Infarct Size Including the Effects of Secondary Injury?Cerebrovascular diseases (Basel, Switzerland) · 2025Article
- Large vessel occlusion mediated fluid attenuated inversion recovery signal intensity ratio is associated with stroke within 4.5 h.Frontiers in neurology · 2024Article
- Variability assessment of manual segmentations of ischemic lesion volume on 24-h non-contrast CT.Neuroradiology · 2022Article
- Tissue outcome prediction in hyperacute ischemic stroke: Comparison of machine learning models.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Temporally distinct myeloid cell responses mediate damage and repair after cerebrovascular injury.Nature neuroscience · 2021Article
- Identifying perfusion deficits on CT perfusion images using temporal similarity perfusion (TSP) mapping.European radiology · 2019Article
- Article
- Reduced Upper Limb Recovery in Subcortical Stroke Patients With Small Prior Radiographic Stroke.Frontiers in neurology · 2019Article
- An MRI Hyperintense Acute Reperfusion Marker Is Related to Elevated Peripheral Monocyte Count in Acute Ischemic Stroke.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2018Article
- Volume Measurement by Diffusion-Weighted Imaging in Cervical Cancer.Yonago acta medica · 2017Article
- Are Movement Artifacts in Magnetic Resonance Imaging a Real Problem?-A Narrative Review.Frontiers in neurology · 2017Review
- A benchmarking tool to evaluate computer tomography perfusion infarct core predictions against a DWI standard.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2016Article
- Magnetic Resonance Imaging in Acute Ischemic Stroke Patients with Mild Symptoms: An Opportunity to Standardize Intravenous Thrombolysis.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2015Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
Abstract
background and purposeWe investigated the intra- and interrater reliability of ischemic lesion volumes measurements assessed by different MRI sequences at various times from onset.
methodsIschemic lesion volumes were measured for intrarater reliability using diffusion-weighted (DWI), mean transit time (MTT) perfusion and fluid-attenuated inversion recovery (FLAIR) MRI at chronic (>3 days from stroke onset) time points. A single intrarater reader, blind to clinical information and time point, repeated the volume measurements on two occasions separated by at least 1 week. Interrater reliability was also obtained in the second set of patients using acute DWI, MTT and chronic FLAIR MRI. Four blinded readers performed these volume measurements. Average deviations across repeat measurements per lesion and differences between sample means between the two measurements were calculated globally, ie, across all sequences and time points, and per reader type for each sequence at each time point.
resultsThere was good concordance of the mean sample volumes of the 2 intrarater readings (deviations were <4% and 2 mL globally, <2% and 2 mL for DWI, <6% and 7 mL for MTT, and <2% and 1 mL for FLAIR). There was also good concordance of the interrater readings (<5% and 2 mL globally).
conclusionsRepeat measurements of stroke lesion volumes show excellent intra- and interrater concordance for DWI, MTT and FLAIR at acute through chronic time points.
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