ArticleBlood2007
Progressive immunoglobulin gene mutations in chronic lymphocytic leukemia: evidence for antigen-driven intraclonal diversification.
Article in Blood, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- SET alpha and SET beta mRNA isoforms in chronic lymphocytic leukaemia.British journal of haematology · 2019Trial
- Article
- Old and New Facts and Speculations on the Role of the B Cell Receptor in the Origin of Chronic Lymphocytic Leukemia.International journal of molecular sciences · 2022Review
- Post-Transformation IGHV-IGHD-IGHJ Mutations in Chronic Lymphocytic Leukemia B Cells: Implications for Mutational Mechanisms and Impact on Clinical Course.Frontiers in oncology · 2021Article
- AID in Chronic Lymphocytic Leukemia: Induction and Action During Disease Progression.Frontiers in oncology · 2021Review
- A method for the isolation and characterization of functional murine monoclonal antibodies by single B cell cloning.Journal of immunological methods · 2017Article
- Article
- Double IGHV DNA gene rearrangements in CLL: influence of mixed-mutated and -unmutated rearrangements on outcomes in CLL.Blood cancer journal · 2016Article
- Interrogation of individual intratumoral B lymphocytes from lung cancer patients for molecular target discovery.Cancer immunology, immunotherapy : CII · 2016Article
- A tool kit for rapid cloning and expression of recombinant antibodies.Scientific reports · 2014Article
- Network properties derived from deep sequencing of human B-cell receptor repertoires delineate B-cell populations.Genome research · 2013Article
- Chronic lymphocytic leukemia and regulatory B cells share IL-10 competence and immunosuppressive function.Leukemia · 2013Article
- Immunologic aspects of monoclonal B-cell lymphocytosis.Immunologic research · 2011Review
- Review
- Intraclonal cell expansion and selection driven by B cell receptor in chronic lymphocytic leukemia.Molecular medicine (Cambridge, Mass.) · 2011Article
- Article
- Single-cell analysis reveals oligoclonality among 'low-count' monoclonal B-cell lymphocytosis.Leukemia · 2010Article
- High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies.Journal of virological methods · 2009Article
- Article
- Apolipoprotein E genotype as a determinant of survival in chronic lymphocytic leukemia.Leukemia · 2008Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Somatic mutations of immunoglobulin genes characterize mature memory B cells, and intraclonal B-cell diversification is typically associated with expansion of B-cell clones with greater affinity for antigen (antigen drive). Evidence for a role of antigen in progression of intraclonal chronic lymphocytic leukemia (CLL) cell diversification in patients with mutated immunoglobulin genes has not been previously presented. We performed a single-cell analysis of immunoglobulin heavy and light chains in 6 patients with somatically mutated CLL-cell immunoglobulin genes and identified 2 patients with multiple related (oligoclonal) subgroups of CLL cells. We constructed genealogic trees of these oligoclonal CLL-cell subgroups and assessed the effects of immunoglobulin somatic mutations on the ratios of replacement and silent amino acid changes in the framework and antigen-binding regions (CDRs) of the immunoglobulin heavy and light chains from each oligoclonal CLL-cell population. In one subject, the amino acid changes were consistent with an antigen-driven progression of clonally related CLL-cell populations. In the other subject, intraclonal diversification was associated with immunoglobulin amino acid changes that would have likely lessened antigen affinity. Taken together, these studies support the hypothesis that in some CLL cases intraclonal diversification is dependent on antigen interactions with immunoglobulin receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.