Trial reportCritical care (London, England)2006
Reduction of nosocomial pneumonia after major burns by trace element supplementation: aggregation of two randomised trials.
Trial report in Critical care (London, England), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 143 citations in OpenAlex.
- Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012.Intensive care medicine · 2013Guideline
- High-dose selenium reduces ventilator-associated pneumonia and illness severity in critically ill patients with systemic inflammation.Intensive care medicine · 2011Trial
- The Role of Zinc Against Bacterial Infections in Neonates, Children, and Adults: A Scoping Review from the Available Evidence of Randomized Controlled Trials About Zinc Supplementation to New Research Opportunities.Antibiotics (Basel, Switzerland) · 2026Review
- Trace elements: Clinical perspectives in the critically ill.Journal of the Intensive Care Society · 2025Review
- Serum Selenium-Binding Protein 1 (SELENBP1) in Burn Injury: A Potential Biomarker of Disease Severity and Clinical Course.Antioxidants (Basel, Switzerland) · 2023Article
- Combined copper and zinc deficiency is associated with reduced SARS-CoV-2 immunization response to BNT162b2 vaccination.Heliyon · 2023Article
- Role of Selenoproteins in Bacterial Pathogenesis.Biological trace element research · 2019Review
- Preoperative patient preparation in enhanced recovery pathways.Journal of anaesthesiology, clinical pharmacology · 2019Review
- Sodium Selenite Acts as an Otoprotectant against Neomycin-Induced Hair Cell Damage in a Zebrafish Model.PloS one · 2016Article
- The role of antioxidant micronutrients in the rate of recovery of burn patients: a systematic review.Burns & trauma · 2016Review
- The effect of parenteral selenium on outcomes of mechanically ventilated patients following sepsis: a prospective randomized clinical trial.Annals of intensive care · 2015Article
- Ten tips for managing critically ill burn patients: follow the RASTAFARI!Intensive care medicine · 2015Article
- Metabolic and nutritional support of critically ill patients: consensus and controversies.Critical care (London, England) · 2015Review
- The effect of dietary intake of antioxidant micronutrients on burn wound healing: a study in a tertiary health institution in a developing country.Burns & trauma · 2015Article
- Burns in children: standard and new treatments.Lancet (London, England) · 2014Review
- Disease-specific nutrition therapy: one size does not fit all.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2013Article
- Enteral nutrition support in burn care: a review of current recommendations as instituted in the Ross Tilley Burn Centre.Nutrients · 2012Review
- Nutrition in burns: Galveston contributions.JPEN. Journal of parenteral and enteral nutrition · 2011Review
- Effect of antioxidants on the incidence of wound infection in burn patients.Annals of burns and fire disasters · 2010Article
- Congestive heart failure: where homeostasis begets dyshomeostasis.Journal of cardiovascular pharmacology · 2010Article
Corrections and comments
- Commented on by
Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionNosocomial pneumonia is a major source of morbidity and mortality after severe burns. Burned patients suffer trace element deficiencies and depressed antioxidant and immune defences. This study aimed at determining the effect of trace element supplementation on nosocomial or intensive care unit (ICU)-acquired pneumonia.
methodsTwo consecutive, randomised, double-blinded, supplementation studies including two homogeneous groups of 41 severely burned patients (20 placebo and 21 intervention) admitted to the burn centre of a university hospital were combined. Intervention consisted of intravenous trace element supplements (copper 2.5 to 3.1 mg/day, selenium 315 to 380 mug/day, and zinc 26.2 to 31.4 mg/day) for 8 to 21 days versus placebo. Endpoints were infections during the first 30 days (predefined criteria for pneumonia, bacteraemia, wound, urine, and other), wound healing, and length of ICU stay. Plasma and skin (study 2) concentrations of selenium and zinc were determined on days 3, 10, and 20.
resultsThe patients, 42 +/- 15 years old, were burned on 46% +/- 19% of body surface: the combined characteristics of the patients did not differ between the groups. Plasma trace element concentrations and antioxidative capacity were significantly enhanced with normalisation of plasma selenium, zinc, and glutathione peroxidase concentrations in plasma and skin in the trace element-supplemented group. A significant reduction in number of infections was observed in the supplemented patients, which decreased from 3.5 +/- 1.2 to 2.0 +/- 1.0 episodes per patient in placebo group (p < 0.001). This was related to a reduction of nosocomial pneumonia, which occurred in 16 (80%) patients versus seven (33%) patients, respectively (p < 0.001), and of ventilator-associated pneumonia from 13 to six episodes, respectively (p = 0.023).
conclusionEnhancing trace element status and antioxidant defences by selenium, zinc, and copper supplementation was associated with a decrease of nosocomial pneumonia in critically ill, severely burned patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.