ArticleMolecular and cellular biology1991
Two regions of the mouse mammary tumor virus long terminal repeat regulate the activity of its promoter in mammary cell lines.
Article in Molecular and cellular biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 85 citations in OpenAlex.
- Mouse Mammary Tumor Virus (MMTV) and MMTV-like Viruses: An In-depth Look at a Controversial Issue.Viruses · 2022Review
- Regulation of Expression and Latency in BLV and HTLV.Viruses · 2020Review
- Divergent Binding and Transactivation by Two Related Steroid Receptors at the Same Response Element.The Journal of biological chemistry · 2016Article
- Divergent human remodeling complexes remove nucleosomes from strong positioning sequences.Nucleic acids research · 2010Article
- Bacillus anthracis lethal toxin represses MMTV promoter activity through transcription factors.Journal of molecular biology · 2009Article
- A composite intronic element directs dynamic binding of the progesterone receptor and GATA-2.Molecular endocrinology (Baltimore, Md.) · 2009Article
- Glucocorticoid receptor haploinsufficiency causes hypertension and attenuates hypothalamic-pituitary-adrenal axis and blood pressure adaptions to high-fat diet.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2008Article
- A 5' distal palindrome within the mouse mammary tumor virus-long terminal repeat recruits a mammary gland-specific complex and is required for a synergistic response to progesterone plus prolactin.Journal of molecular endocrinology · 2008Article
- Chromatin remodeling complexes interact dynamically with a glucocorticoid receptor-regulated promoter.Molecular biology of the cell · 2008Article
- Promoter complex in the central part of the mouse mammary tumor virus long terminal repeat.Journal of virology · 2007Article
- Ligand-specific dynamics of the androgen receptor at its response element in living cells.Molecular and cellular biology · 2007Article
- Article
- ATP-dependent mobilization of the glucocorticoid receptor during chromatin remodeling.Molecular and cellular biology · 2002Article
- The mouse mammary tumor virus transcription enhancers for hematopoietic progenitor and mammary gland cells share functional elements.Journal of virology · 2000Article
- Discrete promoter elements affect specific properties of RNA polymerase II transcription complexes.Nucleic acids research · 2000Article
- CDP is a repressor of mouse mammary tumor virus expression in the mammary gland.Journal of virology · 2000Article
- Hormone activation induces nucleosome positioning in vivo.The EMBO journal · 2000Article
- A ligand binding domain mutation in the mouse glucocorticoid receptor functionally links chromatin remodeling and transcription initiation.Molecular and cellular biology · 1999Article
- Homeoproteins CDP and SATB1 interact: potential for tissue-specific regulation.Molecular and cellular biology · 1999Article
- Mouse mammary tumor virus sequences responsible for activating cellular oncogenes.Journal of virology · 1998Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In vivo expression of the mouse mammary tumor virus (MMTV) is restricted to a few organs, with the highest rate of transcription found in the mammary gland. Using a series of mammary and nonmammary murine cell lines, we have identified two regulatory elements, located upstream of the hormone responsive element, that specifically regulate the MMTV promoter. The first element displays an enhancerlike activity and is coincident with the binding of a nuclear factor (designated MP4; position -1078 to -1052 in the long terminal repeat) whose presence is apparently restricted to mammary cell lines. The second regulatory region mediates a repressive activity and is mapped to the long terminal repeat segment from -415 to -483. This repression is specific for a particular subtype of mammary cells (RAC cells) able to grow under two differentiation states (A. Sonnenberg, H. Daams, J. Calafat, and J. Hilgers, Cancer Res. 46:5913-5922, 1986). The MMTV promoter in mammary cell lines thus appears to be modulated by two cis-acting elements that are likely to be involved in tissue-specific expression in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.