Evidence map›Paper›PMID 17080313›Full record

ReviewNeurochemical research2007

The CNS synapse revisited: gaps, adhesive welds, and borders.

Nazlie S Latefi, David R Colman

Abstract readReview
PubMed Publisher
In one paragraph

Review in Neurochemical research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Ultrastructure of synapses in the mammalian brain.Cold Spring Harbor perspectives in biology · 2012
    Review
  3. Article
  4. SynCAMs organize synapses through heterophilic adhesion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Nazlie S LatefiDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, BT-105, H3A2B4, Montreal, QC, Canada. nazlie.sadeghi@mcgill.ca
David R Colman

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although processes leading up to the point of synapse formation are fairly well understood, the precise sequence of events in which the membranes of two separate cells "lock in" to form a mature synaptic junctional complex is poorly understood. A careful study of the molecules operating at the synapse indicates that their roles are more multifarious than once imagined. In this review we posit that the synapse is a functional organelle with poorly defined boundaries and a complex biochemistry. The role of adhesion molecules, including the integration of their signaling and adhesive properties in the context of synaptic activity is discussed.

Indexed as

AnimalsCell Adhesion MoleculesNeurogliaNeuronal PlasticityNeuronsSignal TransductionSynapsesCell Adhesion Molecules

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.