ReviewHernia : the journal of hernias and abdominal wall surgery2006
Collagen in colon disease.
Review in Hernia : the journal of hernias and abdominal wall surgery, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Genetic, epigenetic and environmental factors in diverticular disease: systematic review.BJS open · 2024Pooled it
- The human colon: Evidence for degenerative changes during aging and the physiological consequences.Neurogastroenterology and motility · 2025Review
- Prior abdominal surgery as a potential risk factor for colonic diverticulosis or diverticulitis.World journal of clinical cases · 2023Article
- Histochemical and biochemical analysis of collagen content in formalin-fixed, paraffin embedded colonic samples.MethodsX · 2023Article
- Lack of autoantibodies against collagen and related proteins in collagenous colitis.BMC immunology · 2022Article
- Hernia and Cancer: The Points Where the Roads Intersect.Frontiers in surgery · 2019Review
- Colonic diverticulosis is associated with abdominal wall hernia.Hernia : the journal of hernias and abdominal wall surgery · 2017Article
- Growth hormone abolishes the negative effects of everolimus on intestinal wound healing.World journal of gastroenterology · 2016Article
- Surgical diverticulitis is not associated with defects in the expression of wound healing genes.International journal of colorectal disease · 2015Article
- A primer on wound healing in colorectal surgery in the age of bioprosthetic materials.Clinics in colon and rectal surgery · 2014Review
- Systemic hernial disease protects against cancer: an hypothesis.Hernia : the journal of hernias and abdominal wall surgery · 2010Article
- Herniology: past, present, and future.Hernia : the journal of hernias and abdominal wall surgery · 2009Review
- High expression of HSP47 in ulcerative colitis-associated carcinomas: proteomic approach.British journal of cancer · 2009Article
- Is herniosis the single etiology of Saint's triad?Hernia : the journal of hernias and abdominal wall surgery · 2009Article
- Volume calculation of rats' organs and its application in the validation of the volume relation between the abdominal cavity and the hernial sac in incisional hernias with "loss of abdominal domain".Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgeryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathophysiology of wound healing in the bowel wall suggests that collagen and matrix metalloproteinases (MMPs) have an important role in the changes of the bowel wall seen in several colonic diseases. Several recent studies suggest that disturbances of the collagen texture and the extracellular matrix (ECM) metabolism are major factors leading to the onset of diverticular disease. Changes of the ECM also play a role in the development of inflammatory bowel diseases. Regarding the permanent remodeling of the bowel wall, any imbalance of the ECM could support the onset of chronic inflammation and the development of fistula formation, such as that seen in patients with Crohn's disease. Disturbances of the ECM play a role in the pathogenesis of anastomotic leakage after large bowel surgery and suggest the presence of a genetically defined risk population with disturbed wound healing mechanisms. This concept could explain the well known situation where an anastomotic breakdown is observed, despite the absence of other known risk factors and after a technically correct anastomosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.